Genmab — Marts 2020

[Thetreble]

Sarclisa fra Sanofi bliver billigere end Genmab - er dette middel en trussel mod dara salget ?

[GeorgeBest]

Ja i tredie linie er det. Vincent Rajkumar har på Twitter meddelt at han vil bruge Sarclisa i Pom/Dex kombien hvis det er billigere...

[GeorgeBest]

Sarclisa er kun godkendt til tredie linie plus patienter, så i første og anden linie er det ikke en trussel, og det er langt det største marked

[GeorgeBest]

Nogen der ved hvornår Sarclisa kan blive godkendt i 1. og 2. linie?

[Bulder]

2. linje dette her fase 3 - Ikema: https://www.clinicaltrials.gov/ct2/show/NCT03275285?term=isatuximab+mm&draw=2&rank=4

[Bulder]

Det eneste 1. linje jeg har kunnet finde er dette fase 1: https://www.clinicaltrials.gov/ct2/show/NCT02513186?term=isatuximab+mm&draw=2&rank=2

[Bulder]

Så Ikema i 2. linje bliver det næste med primary completion til november og tidligst godkendelse sidst i 2021.

[GeorgeBest]

Tak Bulder

[E_L]

this NKTCL trial was recently completed; should we expect a Ph III trial to be started? https://clinicaltrials.gov/ct2/show/NCT02927925?term=NKTCL+AND+daratumumab&draw=2&rank=1

[GeorgeBest]

There were some years ago stories about fantastic outcome for some patients with NKTCL who received dara. But since then it has been quite.

[Bulder]

Conclusions: DARA 16 mg/kg was well tolerated with no new safety concerns, and only 2 patients discontinuing due to TEAEs. DARA monotherapy demonstrated an encouraging response rate (ORR: 25%) in pts with R/R NKTCL and warrants further study in this poor prognosis pt population. https://ashpublications.org/blood/article/134/Supplement_1/1568/427350/Daratumumab-Monotherapy-for-Patients-with-Relapsed

[Bulder]

Spørgsmålet er så om det var opmuntrende nok

[E_L]

1513.5 low vs last weeks' 1504.5 ; lets hope it will turn into a double bottom....

[Helge_LarsenPI-redaktør]

Genmab is proud to be on the 2020NJBIZ BestPlacesNJ to work list: https://njbiz.com/best-places-to-work-in-nj-2020/

[nohope]

Hmm - mon ikke det er sådan en liste over - lidet at bestille og meget at fortjene top ti?

[nohope]

Deres excellence, det maatte være et embede, hvorved der var meget at fortjene og lidet at bestille; thi dertil føler jeg mig mest oplagt.

[Solsen]

Lol

[Helge_LarsenPI-redaktør]

[bongobob]

Se seneste slide ware fra Genmab side 33. DR5/DR5 er MEGET potent https://ir.genmab.com/static-files/50a5c114-5126-45a8-9d6f-17b883705a16

[bongobob]

Bla dette: 23% tumor shrinkage after single dose in a patient with CRC