Genmab — Juni 2019

[JKY_VH]

Tjah, nu må snart kravle ned af træet igen:-)

[JKY_VH]

han

[E_L]

@lahn1 we are only talking development costs now so far; once JNJ triggers the option to co-develop, they will start sharing the cost. And that is when i gets expensive, think of the large trials they have been doing with Dara

[Sibelius]

Det er også en "get-out of jail" aftale idet at hvis JNJ ikke vil udnytte optionen (og midlet virker" er Genmab frit stillet til selv at markedsføre

[Darvin]

Som jeg læser teksten er de langt. De har gode prekliniske data og som de skriver could be superior to daratumumab for certain tumor cell types. Måske ikke langt fra at de er klar til næste skridt.

[Bulder]

@E L: I think it's developing, not co-developing. If Janssen exercises the option they'll take over all the costs - as I see it.

[E_L]

oh really, i read that wrong then; that is a BIG difference!

[E_L]

think you are correct. makes sense also really, given the current Dara deal, they are extending and improving that

[JKY_VH]

Enig Bulder, det er vel ret beset også det Ritzau skriver "Baseret på data fra Genmabs studier, kan Janssen så vælge at udnytte sin option på at udvikle, fremstille og markedsføre Hexabody-CD38. Sker det, vil Janssen betale Genmab 150 mio. dollar, eller knap 1 mia. kr., for at udnytte optionen."

[kkjoel]

Ja, de overtager (udvikling OG omkostninger): "Based on the data from these studies, Janssen may exercise its option and receive a worldwide license to develop, manufacture and commercialize HexaBody-CD38." Sådan må man læse det.

[JKY_VH]

præcis

[E_L]

And it was all predicted here before! "10/4 11:07
af Sukkeralf
That should maybe be hexaboost as life cicle management" "well, yes, that would be an interesting development; are you thinking a HexaDara to increase patent life and some extra Hexa licencing money? I like it "

[Bulder]

Har vi hørt om hexabody cd38 før? Jeg synes ikke at kunne finde nogen IND/CTA undervejs?

[E_L]

i haven't seen it before, no

[E_L]

next question is; will it work in solids

[bibob]

Lets hope so.

[Bulder]

There is not that much cd38 on solid tumors. The reason why dara was thought to be effective in solids was that it could strengthen the efficacy of a PD(L)-1 inhibitor by blocking cd38. I don't know if a boosted cd38 would be of any help here. But I think we need Sukkeralf on this subject.

[Sukkeralf]

If I remember correctly Jans first thoughts of new INDs for 2019 was 3-5 and recently it was 3 (and we know them all) but maybe HexaCD38 could have been close so I hope it will be a 2020 IND

[lahn1]

@09:28 yes I see that now. It stille feels early to do this deal, hence the "pure milestone
payement"

[Sukkeralf]

But the deal need to be in place for Genmab to do the costly preclinical work