Genmab — Februar 2019

[StockBull]

EPS

[StockBull]

Burde give minimum 500 kr paa kursen

[StockBull]

Men her og nu vel omkring 100 kr efter min mening

[Solsen]

Enig. Men forudsætningerne skal holde

[troldmanden]

husk på at hvis Genmab mener det er kurspåvirkene info så er de forpligtet til straks at sende en fondsbørsmeddelelse ud. Og det er ikke sket......

[peter12]

Det påvirker vel kun budgettet for 2019 negativt pt

[Skod]

Har læst Myginds indlæg et par gange, og jeg synes ikke jeg kan se de 2 mia. er et topsalgsestimat, blot et salgestimat allerede om 5 år. Virker det ikke urealistikt at ramme topsalget så tidligt, når vi kun lige har opdaet at der er en bjørn vi måske kan skyde et sted? Kan der være mere end 2 mia. i det i topsalg, eller er det underforstået at han mener topsalg
?

[peter12]

Genmab har vel informeret alt det de skal. De er jo ikke forpligtet til at sige hvad det sælger om 5 år. Den Børsen artikelMygind linker til, forklarer det vist meget godt

[StockBull]

Ja 2019 negativt peter men fra 2020 er TV vel selvfinanceret og giver lidt overskud forhaabentligt

[StockBull]

Sammen med OFA kan det vel blive 5 bn inden 2025

[StockBull]

Saa + 13 bn med dara

[E_L]

Am I correct that -the Lancet focus is on safety data, and further mentions that for the whole TV201 cOR=15.6%

[E_L]

-that then Professor de Bono explained to other press that cohorts of patients with bladder cancer and cervical cancer showed 27 % respectively 26.5 % response (Confirmed response?) –which is basically what we know from ESMO?

[Bulder]

From the full Lancet article: Although this trial was not designed or powered to
assess antitumour activity, we report encouraging
preliminary antitumour activity for tisotumab vedotin in
a broad population of patients with heavily pretreated,
locally advanced or metastatic (or both) cancers of the
bladder, cervix, endometrium, oesophagus, lung, and
ovary.

[Bulder]

More: Limitations of this phase 1–2 open-label study include a
small sample size in some tumour types and the absence
of overall survival as a prespecified endpoint.

[Bulder]

Several studies are underway,
including InnovaTV 207 and InnovaTV 204. InnovaTV 207
(NCT03485209) is an ongoing phase 2 study evaluating
the activity, safety, and tolerability of tisotumab vedotin
monotherapy administered every 3 weeks in patients
with relapsed, locally advanced or metastatic colorectal
cancer, squamous non-small-cell lung cancer, pancreatic
cancer, or squamous cell carcinoma of the head and
neck.

[Bulder]

Following on from the encouraging preliminary activity seen in the cervical cancer cohort in this
study, InnovaTV 204 (NCT03438396) is an ongoing
phase 2 study evaluating the activity, safety, and
tolerability of tisotumab vedotin monotherapy in patients
with recurrent or metastatic cervical cancer that had
progressed during or after treatment with standard firstline therapy.

[Bulder]

So the resonserates mentioned are not final, but must be confirmed in follow up studies.

[Bulder]

@ Pensionisten: Så det videre forløb er InnovaTV 204 og 207, som skal bekræfte data.

[E_L]

great, thanks @Bulder (- i only have the summary article so far)