Genmab — November 2018

kkjoel

Så vi er vist mange der prøver at holde
håret fast klinet til hovedbunden, når tal, fagsnak, -termer og -forkortelser fyger henover instrumentbrædtet

Solsen

Genmab har igennem innovation fået frembragt nogle unikke duobodies/haxabodies/duohexabodies der er yderst potente. Nu skal de gennem nåleøjet i kliniske forsøg for muligvis blive til cash cows. Det bliver interessant at følge. Dara sc er home run og bjerget er daras (citat fra FS).

E_L

SC looks indeed very good. Very much undervalued still i believe. hopefully this ASH it's importance will be a bit more highlighted.

Solsen

We surely get updated data from PAVO. Do anyone recall when we get the ph3 study ready. I belive JW have said january 19. But expectations are some month later by analyst.

Bulder

I don't rember Winkel having said January. But Novod have spoken about Q1.

Solsen

When dosing in iv was fixed it was on a very few pts I recall. So the higher conc. in blood could very well be a gamechanger.
We know SAE is much better in sc and the bottleneck related to infusion time are gone with the 3-5 min sc

Solsen

Thanks bulder !

JørgenVarnæs

do we know that SC eliminates the initial administration issues?

JørgenVarnæs

or is that something we still need to see from the studies?

E_L

not a complete answer JV, but close, maybe we hear more in the actual presentation https://ash.confex.com/ash/2018/webprogram/Paper113590.html

Bulder

It looks like there still is a bit of IRRs in the first dose, but much les than IV: The incidence (16%) and severity of IRRs (mostly grade 1-2) with DARA SC was low, the majority of which occurred on Cycle 1 Day 1, and no discontinuations due to IRRs were observed.

Bulder

They still talk only about 3-5 minutes. Could be 5 minutes first time, then 3 min thereafter.

E_L

It would be hard anyhow, right? with IV they often stop for a while/pauze on the first day in case of problems, but if you get a 5 minute shot, there is little time to stop lol

JørgenVarnæs

from what i recall - SC is being tested "stand-alone". The first dose is also SC. But I'm guessing an SC dose as an out patient is much easier/faster than the two-day IV first dose

JørgenVarnæs

Bulder - do you know if SC first dose is administered at home or under supervision?

JørgenVarnæs

But SC administration will eliminate the bottleneck issues no matter where it is administered

Bulder

In a clinic. According to Winkel home-administration is not possible at all.

JørgenVarnæs

also for the subsequent doses?

Bulder

Could be a good Q for the Q&A

E_L

Do I have this right on AMG420; they started this study in 2015, recruited only 35 patients of which 21 had disease progression , but they are talking positive about the 5(!!) that are still remaining?