Genmab — November 2018

E_L

https://getvisualtv.net/stream/?aarhus-symposium-2018-1 watch now Jan live

E_L

and over already lol

Solsen

Dara SC (CF) coformulation udgaven med 1800 mg dara giver min. en 50% højere koncentration af aktivstoffet i blodet end den traditionelle iv 16 mg/kg https://ash.confex.com/ash/2018/webprogram/Paper113161.html

Solsen

Ikke underligt af effekten sikkert er bedre.

kkjoel

Tror jeg går i dine fodspor bibbe.. men åbner en god flaske øl i aften (t hjemmelavet burger). Vinen blir først i morgen.

kkjoel

Fantastisk måned vi har haft - først kyler hysteriske investorer os i helvedesdybet pga. nogle (indtil andet vides) engangsrabatter og små bitte forsinkelser ift. oprindeligt udmeldte MAIA-data datoer.. så kører vi op igen da forventeligt fine MAIA-data og forventeligt gode ASH-data kommer. Hvem der havde haft en ekstra formue at indkøbe for i 800.......
!

kkjoel

Og endnu enagng tusind tak til vore utrættelige og videnede eksperter herinde. Hvad i alverden skal man bruge bankernes investeringsrådgivere til i dette tilfælde??? God weekend til alle

kkjoel

Ja altså, det er jo ikke kun penge det hele - antistoffer er et meget interessant område, men frygteligt komplekst.

kkjoel

Så vi er vist mange der prøver at holde
håret fast klinet til hovedbunden, når tal, fagsnak, -termer og -forkortelser fyger henover instrumentbrædtet

Solsen

Genmab har igennem innovation fået frembragt nogle unikke duobodies/haxabodies/duohexabodies der er yderst potente. Nu skal de gennem nåleøjet i kliniske forsøg for muligvis blive til cash cows. Det bliver interessant at følge. Dara sc er home run og bjerget er daras (citat fra FS).

E_L

SC looks indeed very good. Very much undervalued still i believe. hopefully this ASH it's importance will be a bit more highlighted.

Solsen

We surely get updated data from PAVO. Do anyone recall when we get the ph3 study ready. I belive JW have said january 19. But expectations are some month later by analyst.

Bulder

I don't rember Winkel having said January. But Novod have spoken about Q1.

Solsen

When dosing in iv was fixed it was on a very few pts I recall. So the higher conc. in blood could very well be a gamechanger.
We know SAE is much better in sc and the bottleneck related to infusion time are gone with the 3-5 min sc

Solsen

Thanks bulder !

JørgenVarnæs

do we know that SC eliminates the initial administration issues?

JørgenVarnæs

or is that something we still need to see from the studies?

E_L

not a complete answer JV, but close, maybe we hear more in the actual presentation https://ash.confex.com/ash/2018/webprogram/Paper113590.html

Bulder

It looks like there still is a bit of IRRs in the first dose, but much les than IV: The incidence (16%) and severity of IRRs (mostly grade 1-2) with DARA SC was low, the majority of which occurred on Cycle 1 Day 1, and no discontinuations due to IRRs were observed.

Bulder

They still talk only about 3-5 minutes. Could be 5 minutes first time, then 3 min thereafter.