Genmab — November 2018
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do we know that SC eliminates the initial administration issues?
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or is that something we still need to see from the studies?
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not a complete answer JV, but close, maybe we hear more in the actual presentation https://ash.confex.com/ash/2018/webprogram/Paper113590.html
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It looks like there still is a bit of IRRs in the first dose, but much les than IV: The incidence (16%) and severity of IRRs (mostly grade 1-2) with DARA SC was low, the majority of which occurred on Cycle 1 Day 1, and no discontinuations due to IRRs were observed.
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from what i recall - SC is being tested "stand-alone". The first dose is also SC. But I'm guessing an SC dose as an out patient is much easier/faster than the two-day IV first dose
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Bulder - do you know if SC first dose is administered at home or under supervision?
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But SC administration will eliminate the bottleneck issues no matter where it is administered
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also for the subsequent doses?
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I had a gander at the durability of the drug - seems if it is refrigerated dara has a shelf life of 24 months
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you can keep dara in your fridge at home and shoot it just like insulin
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