Genmab — Oktober 2018

[bongobob]

Kun en overskrift: https://www.sciencedirect.com/science/article/pii/S0161589018304255?via%3Dihub

[bongobob]

Hexamerization-enhanced CD37 and CD20 antibodies synergize in CDC to kill patient-derived CLL cells with unprecedented potency

[bongobob]

DuoHexa CD37 i kombi med CD20. Vi får nok masser af denne type nyheder det næste år

[Bulder]

De skal være velkomne

[OHW]

arhg...patienterne er nok ikke enige med dig!

[Doc4]

9:05..However, resistance of cancer cells to CDC is a major problem.
Two FDA-approved CD20 IgG1 mAbs, rituximab and ofatumumab,
promote only ∼15 and 50% CDC, respectively, of B cells from
patients with chronic lymphocytic leukemia (CLL)...we report that hexamerization-enhanced mAbs, specific for CD20
or CD37, induced 95–99% CDC of CLL B cells at concentrations of
10–16 g/mL in samples from 20 patients. CD37 mAbs without the
E430G mutation did not mediate CDC...

[Doc4]

...High levels of killing of primary cancer cells are
unprecedented and provide new opportunities for development of
improved antibody therapies exploiting CDC, particularly in CLL.

[E_L]

Daratumumab in myeloma update: expanding indications, Niels van de Donk @ ESH - https://www.youtube.com/watch?v=66TVQeKcp38

[E_L]

Update on recent smoldering multiple myeloma trials, Maria-Victoria Mateos @ESH https://www.youtube.com/watch?v=sF_fmbhnc0s

[E_L]

CD38 antibodies under investigation for myeloma: isatuximab, MOR202 & TAK-079 https://www.youtube.com/watch?v=8-oiXhcegjw

[E_L]

Updated CASTOR analysis: daratumumab plus Vd for R/R myeloma https://www.youtube.com/watch?v=2dwYLNTA19s

[Bulder]

Så fik vi median. pfs for Castor DVd: aproxx 2 years vs 7 mdr. for Vd og 26 mdr for 1. relaps DVd.

[mobbyduck1]

ja det er imponerende

[mobbyduck1]

og vi ved at Pollux er endnu bedre

[mobbyduck1]

og 43% CR i 1.Relaps er det også mere end fint

[Bulder]

42 % fik komplet respons efter 1. relaps. Førhen så man slet ikke CR i relapsed setting. Det var kun noget der forekom i 1. linje.

[Bulder]

43% - jeg hørte forkert

[mobbyduck1]

sorry 43

[Helge_LarsenPI-redaktør]

Tusinde tak for link Bulder. http://www.proinvestor.com/index.php?p=debat_1&postid=76324

[Bulder]

Det var nu E L. As usual, one could say.