Genmab — April 2018

[Legolas23]

[Parasitism]

God morgen

[bibob]

God morgen.

[polle1]

Der kommer måske ikke nogen tal idag ?

[jkj]

jo, men interessen for at opstøve dem, er nok ikke så stor som normalt.

[E_L]

https://twitter.com/DrKantor/status/989020060579704832 - Poster : Ofatumumab (subcutaneous anti-CD20) effects on white blood cells in mice vs. IV version

[E_L]

in a Celgene forum https://www.investorvillage.com/smbd.asp?mb=341&mn=217738&pt=msg&mid=18227297

[gentogen]

Effect of Subcutaneous vs Intravenous Chronic Treatment with an Anti-CD20 Antibody on B-, T- and Myeloid Lymphocyte Subsets in Blood, Lymph Nodes and Spleen of C57BL/6 Mice (P2.410)
Anna Schubart, Gaelle Elain, Cindy Schmid, Julien Perdoux, Catherine Huck, David Leppert, Anis Mir, Gisbert Weckbecker
Neurology Apr 2018, 90 (15 Supplement) P2.410

[gentogen]

Chronic s.c. administration of an anti-CD20 antibody in mice induced a potent and long-lasting depletion of B cells. The quicker B-cell recovery in spleen with s.c. versus i.v. treatment may be linked to more favorable immunosurveillance and thereby may provide a potential benefit for patients requiring treatment cessation

[E_L]

that is a certainly much more easy to read I can't wait to see the Ofa results in MS

[Bulder]

After having enlarged the poster I think(!) it says the same about depletion of B-cells. But also that a reduction of CD4+ and CD8+ T-cells was transient and recovered at day 28(?). Also transient changes in granulocyte counts.

[E_L]

yes, also in that article from gentogen, here the link http://n.neurology.org/content/90/15_Supplement/P2.410

[jkj]

Er der abstrakt frigivelse til ASCO idag ?

[jkj]

Kun titler kan jeg sehttps://iplanner.asco.org/am2017/#/

[jkj]

og kun poster præsentationer kan jeg se.

[jkj]

Zymeworks er udvalgt til oral præsentation for deres ZW25, spændende canadisk biotekselskab som er værd at hold øje med.

[HenryAS]

Nordea skriver idag: Genmab kan komme i fokus efter solide Darzalex-salgstal for marts. Vi er positive på Genmab.

[jkj]

ja det er tydeligt at nordea har set dem og køber ind på dem, men ville nu være rart hvis vi andre også kendte dem.

[AaBforever]

Hvis Nordea har set tallene, så har A/B også.

[HenryAS]

Selve tallene oplyser de ikke iden meddelelse jeg har fået kun ovennævnte at de var solide