Genmab — April 2018
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God morgen
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https://twitter.com/DrKantor/status/989020060579704832 - Poster : Ofatumumab (subcutaneous anti-CD20) effects on white blood cells in mice vs. IV version
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Effect of Subcutaneous vs Intravenous Chronic Treatment with an Anti-CD20 Antibody on B-, T- and Myeloid Lymphocyte Subsets in Blood, Lymph Nodes and Spleen of C57BL/6 Mice (P2.410)
Anna Schubart, Gaelle Elain, Cindy Schmid, Julien Perdoux, Catherine Huck, David Leppert, Anis Mir, Gisbert Weckbecker
Neurology Apr 2018, 90 (15 Supplement) P2.410 -
Chronic s.c. administration of an anti-CD20 antibody in mice induced a potent and long-lasting depletion of B cells. The quicker B-cell recovery in spleen with s.c. versus i.v. treatment may be linked to more favorable immunosurveillance and thereby may provide a potential benefit for patients requiring treatment cessation
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yes, also in that article from gentogen, here the link http://n.neurology.org/content/90/15_Supplement/P2.410
I can't wait to see the Ofa results in MS
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