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Genmab — September 2017

Planlagt Fastgjort Låst Flyttet Genmab
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  • SolsenS Offline
    SolsenS Offline
    Solsen
    wrote on sidst redigeret af
    #335

    Imids stimulere immunforsvaret på en ikke helt afdækket måde. Så to immunmodullerende stoffer sammen kan være en giftig cocktail.

    1 Reply Last reply
    0
    • BulderB Offline
      BulderB Offline
      Bulder
      wrote on sidst redigeret af
      #336

      Er der nogen, der ved hvad Keytruda-patienten egentlig døde af?

      1 Reply Last reply
      0
      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #337

        Omvendt har dara+imid nærmest synergieffekt. Det sås ved dara+pom.

        1 Reply Last reply
        0
        • SolsenS Offline
          SolsenS Offline
          Solsen
          wrote on sidst redigeret af
          #338

          Mon ikke det er CRS, der er problemet. Vi har dog set at man i CAR-T behandlingen kan mindske de problemer med anti Il-6 behandling. CRS=cytokine release syndrom.

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          0
          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #339

            Whatever the problem is, if dara works well enough without PD1 t
            he package will be much cheaper...

            1 Reply Last reply
            0
            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #340

              Der er en kilometerlang liste over Keytruda's genvordigheder, men en søgning på CRS og cytokine gav ikke hug. http://investors.merck.com/news/press-release-details/2017/Merck-Provides-Further-Update-on-Three-Multiple-Myeloma-Studies-Evaluating-KEYTRUDA-pembrolizumab-in-Combination-with-Pomalidomide-or-Lenalidomide/default.aspx

              1 Reply Last reply
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              • SolsenS Offline
                SolsenS Offline
                Solsen
                wrote on sidst redigeret af
                #341

                https://dev.hematology.org/Thehematologist/Diffusion/7617.aspx Fra et fase 2 Pomalidomider/PD1 forsøg. 40% grade 3-4 SAE.

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #342

                  vi må afvente den nærmere afklaring

                  1 Reply Last reply
                  0
                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #343

                    Merck buys Rigontec ; another immuno-oncology combo?
                    http://www.epvantage.com/Universal/View.aspx?type=Story&id=729882&isEPVantage=yes

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                    0
                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #344

                      meanwhile, the company that had to put Opdivo on partial clinical hold , has some succes with.... Opdivo 😉 https://investors.bms.com/iframes/press-releases/press-release-details/2017/CheckMate--214-Study-Evaluating-Opdivo-in-Combination-with-Yervoy-Stopped-Early-for-Demonstrating-Overall-Survival-Benefit-in-Patients-with-Previously-Untreated-Advanced-or-Metastatic-Renal-Cell-Carcinoma/default.aspx

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                      0
                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #345

                        BMY +5% http://www.nasdaq.com/article/bristolmyers-squibb-bmy-has-risen-to-a-new-high-on-phase-3-study-news-20170907-00940

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                        0
                        • S Offline
                          S Offline
                          Sukkeralf
                          wrote on sidst redigeret af
                          #346

                          Thanks E L - thats why Exelixis falls 10%

                          1 Reply Last reply
                          0
                          • S Offline
                            S Offline
                            Sukkeralf
                            wrote on sidst redigeret af
                            #347

                            Access denied | www.fiercebiotech.com used Cloudflare to restrict access | www.fiercebiotech.com | Cloudflare

                            favicon

                            (www.fiercebiotech.com)

                            1 Reply Last reply
                            0
                            • SolsenS Offline
                              SolsenS Offline
                              Solsen
                              wrote on sidst redigeret af
                              #348

                              At specifik ramme de immunsuppressive T-regs virker mere smart 😉

                              1 Reply Last reply
                              0
                              • T Offline
                                T Offline
                                tianc
                                wrote on sidst redigeret af
                                #349

                                Sukkeralf -Kan jeg lokke dig til at forklare kort, hvorfor Exel falder på dette?

                                1 Reply Last reply
                                0
                                • Legolas23L Offline
                                  Legolas23L Offline
                                  Legolas23
                                  wrote on sidst redigeret af
                                  #350

                                  God morn

                                  1 Reply Last reply
                                  0
                                  • B Offline
                                    B Offline
                                    bibob
                                    wrote on sidst redigeret af
                                    #351

                                    God morgen. 🙂

                                    1 Reply Last reply
                                    0
                                    • Helge_LarsenPI-redaktørH Offline
                                      Helge_LarsenPI-redaktørH Offline
                                      Helge_LarsenPI-redaktør
                                      wrote on sidst redigeret af
                                      #352

                                      God morgen. 🙂

                                      1 Reply Last reply
                                      0
                                      • M Offline
                                        M Offline
                                        Mogan
                                        wrote on sidst redigeret af
                                        #353

                                        God morgen 🙂

                                        1 Reply Last reply
                                        0
                                        • J Offline
                                          J Offline
                                          Jedi
                                          wrote on sidst redigeret af
                                          #354

                                          Her er en opsummering af sammenhæng mellem Exel og Opdivo/Yervoy succes i RCC https://seekingalpha.com/news/3294186-exelixis-9-percent-bristol-myers-successful-study-opdivo-yervoy-rcc?app=1&uprof=45&dr=1#email_link

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