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Genmab — September 2017

Planlagt Fastgjort Låst Flyttet Genmab
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  • SolsenS Offline
    SolsenS Offline
    Solsen
    wrote on sidst redigeret af
    #334

    Imids går vel ikke i spænd sammen med PD1

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    0
    • SolsenS Offline
      SolsenS Offline
      Solsen
      wrote on sidst redigeret af
      #335

      Imids stimulere immunforsvaret på en ikke helt afdækket måde. Så to immunmodullerende stoffer sammen kan være en giftig cocktail.

      1 Reply Last reply
      0
      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #336

        Er der nogen, der ved hvad Keytruda-patienten egentlig døde af?

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        0
        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #337

          Omvendt har dara+imid nærmest synergieffekt. Det sås ved dara+pom.

          1 Reply Last reply
          0
          • SolsenS Offline
            SolsenS Offline
            Solsen
            wrote on sidst redigeret af
            #338

            Mon ikke det er CRS, der er problemet. Vi har dog set at man i CAR-T behandlingen kan mindske de problemer med anti Il-6 behandling. CRS=cytokine release syndrom.

            1 Reply Last reply
            0
            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #339

              Whatever the problem is, if dara works well enough without PD1 t
              he package will be much cheaper...

              1 Reply Last reply
              0
              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #340

                Der er en kilometerlang liste over Keytruda's genvordigheder, men en søgning på CRS og cytokine gav ikke hug. http://investors.merck.com/news/press-release-details/2017/Merck-Provides-Further-Update-on-Three-Multiple-Myeloma-Studies-Evaluating-KEYTRUDA-pembrolizumab-in-Combination-with-Pomalidomide-or-Lenalidomide/default.aspx

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                0
                • SolsenS Offline
                  SolsenS Offline
                  Solsen
                  wrote on sidst redigeret af
                  #341

                  https://dev.hematology.org/Thehematologist/Diffusion/7617.aspx Fra et fase 2 Pomalidomider/PD1 forsøg. 40% grade 3-4 SAE.

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #342

                    vi må afvente den nærmere afklaring

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                    0
                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #343

                      Merck buys Rigontec ; another immuno-oncology combo?
                      http://www.epvantage.com/Universal/View.aspx?type=Story&id=729882&isEPVantage=yes

                      1 Reply Last reply
                      0
                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #344

                        meanwhile, the company that had to put Opdivo on partial clinical hold , has some succes with.... Opdivo 😉 https://investors.bms.com/iframes/press-releases/press-release-details/2017/CheckMate--214-Study-Evaluating-Opdivo-in-Combination-with-Yervoy-Stopped-Early-for-Demonstrating-Overall-Survival-Benefit-in-Patients-with-Previously-Untreated-Advanced-or-Metastatic-Renal-Cell-Carcinoma/default.aspx

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                        0
                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #345

                          BMY +5% http://www.nasdaq.com/article/bristolmyers-squibb-bmy-has-risen-to-a-new-high-on-phase-3-study-news-20170907-00940

                          1 Reply Last reply
                          0
                          • S Offline
                            S Offline
                            Sukkeralf
                            wrote on sidst redigeret af
                            #346

                            Thanks E L - thats why Exelixis falls 10%

                            1 Reply Last reply
                            0
                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #347

                              Access denied | www.fiercebiotech.com used Cloudflare to restrict access | www.fiercebiotech.com | Cloudflare

                              favicon

                              (www.fiercebiotech.com)

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                              0
                              • SolsenS Offline
                                SolsenS Offline
                                Solsen
                                wrote on sidst redigeret af
                                #348

                                At specifik ramme de immunsuppressive T-regs virker mere smart 😉

                                1 Reply Last reply
                                0
                                • T Offline
                                  T Offline
                                  tianc
                                  wrote on sidst redigeret af
                                  #349

                                  Sukkeralf -Kan jeg lokke dig til at forklare kort, hvorfor Exel falder på dette?

                                  1 Reply Last reply
                                  0
                                  • Legolas23L Offline
                                    Legolas23L Offline
                                    Legolas23
                                    wrote on sidst redigeret af
                                    #350

                                    God morn

                                    1 Reply Last reply
                                    0
                                    • B Offline
                                      B Offline
                                      bibob
                                      wrote on sidst redigeret af
                                      #351

                                      God morgen. 🙂

                                      1 Reply Last reply
                                      0
                                      • Helge_LarsenPI-redaktørH Offline
                                        Helge_LarsenPI-redaktørH Offline
                                        Helge_LarsenPI-redaktør
                                        wrote on sidst redigeret af
                                        #352

                                        God morgen. 🙂

                                        1 Reply Last reply
                                        0
                                        • M Offline
                                          M Offline
                                          Mogan
                                          wrote on sidst redigeret af
                                          #353

                                          God morgen 🙂

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                                          0

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