Genmab — August 2016
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Astma er (var) i hvert fald eksklusionskriterie i dara mono fase 2 https://www.clinicaltrials.gov/ct2/show/NCT01985126?term=daratumumab+monoclonal&rank=5
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Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma - http://szpiczak.org/lang/aktualnosci/komunikaty/pdf/rok_2016/Practical_considerations_dara_Moreau_Therapy_in_Practice_2016.pdf
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Patients with known chronic obstructive pulmonary disease (COPD) with a forced expiratory volume in 1 s (FEV1) \50 % of predicted normal, or with moderate or severe persistent asthma within the past 2 years, should not receive daratumumab. In fact, FEV1 testing should be performed for patients in whom COPD is suspected, and they must be excluded if FEV1 is \50 % of the predicted value.
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Lidt om genterapiernes anvendelse udenfor cancer - http://medwatch.dk/Medicinal___Biotek/article8887308.ece
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