Genmab — Oktober 2014
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Det er ikke kun dosisændring. I det nye testes ofa som add-on til oral steroid overfor steroid med add-on placebo
. I det gamle er det ofa mod placebo -
Negativt positivt eller hvad ?
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Dog irriterende hvis de starter forfra. Det gamle studie havde jo rekrutteret i over 12 måneder
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Time to sustained remission on minimal steroid therapy [ Time Frame: Up to 60 weeks ] [ Designated as safety issue: No ]
Time from randomization to the time of the subject's initial reduction of prednisone/prednisolone dose to <=10 mg/day and maintained a dose <=10 mg/day with no new or nonhealing (established) lesions for >=8 weeks and maintained the status until Week 60 will be assessed -
MIRROR: Threshold Identified for Ofatumumab Therapy in MS
Results of the phase 2 study suggest that an optimal dose can be found that will give maximal suppression of MS lesions without completely eradicating all B cells.
Medscape (www.medscape.com)
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