Genmab — Maj 2021

Hamming

Lidt konkurrence til Genmab og Biontech
https://www.fiercebiotech.com/biotech/numab-raises-111m-to-challenge-genmab-biontech-for-emerging-pd-l1-opportunity

E_L

JNJ press release - Updated Amivantamab and Lazertinib Combination Data Demonstrate Durable Responses and Clinical Activity for Osimertinib-Relapsed Patients with EGFR-Mutated Non-Small Cell Lung Cancer - https://www.jnj.com/updated-amivantamab-and-lazertinib-combination-data-demonstrate-durable-responses-and-clinical-activity-for-osimertinib-relapsed-patients-with-egfr-mutated-non-small-cell-lung-cancer

E_L

and a bit more on amivantamab https://endpts.com/jj-busts-out-a-small-update-for-its-antibody-tki-combo-in-lung-cancer-whetting-appetites-as-fda-thinks-it-over/

Bulder

thx E L. Easier to understand

E_L

one more then - Biotech
ASCO: Johnson & Johnson's bispecific lung cancer combo shows promise as Tagrisso backup, but the Big Pharma wants more https://www.fiercebiotech.com/biotech/asco-janssen-s-bispecific-lung-cancer-combo-shows-promise-as-tagrisso-back-up-but-big

Sukkeralf

Nice work diggin´ good stuff up

E_L

ASCO : A phase 1b, open-label, dose-escalation study to evaluate camidanlumab tesirine (Cami) as monotherapy in patients (pts) with advanced solid tumors. https://meetinglibrary.asco.org/record/196008/abstract

Bulder

Well, response not impressive. But dont know what to expect in these indications.

E_L

no, maybe we'll hear a bit more in June; this is data from December with only 'Median (range) treatment duration was 22 (1–178) days'

E_L

another maintenance abstract - Daratumumab (DARA) maintenance therapy following DARA + cyclophosphamide, bortezomib, and dexamethasone (CyBorD) induction therapy in multiple myeloma (MM): End-of-study analysis of LYRA https://meetinglibrary.asco.org/record/195444/abstract

E_L

and one more maintenance on the Auriga trial, Dara vs SOC https://meetinglibrary.asco.org/record/201317/abstract

Bulder

I wonder if they'll wait for that study before they file dara as maintenance, or if Cass part 2 is enough.

Bulder

Winkel didn't answer that Q, but on the other hand he said "We fully expect a number of new label extensions to be executed in the coming time."

Bulder

I assume "a number of" is more than 1.

E_L

we'll also see more extensions being requested by other companies , like Amgen for Carfilzomib, just as JNJ included Revlimid in many of the extensions

E_L

or like AbbVie for Lemzoparlimab , whatever that is, never heard of it, New trial - https://clinicaltrials.gov/ct2/show/NCT04895410

E_L

Daratumumab and Pomalidomide in Previously Treated Patients With AL Amyloidosis (DarPAL) - New trial https://clinicaltrials.gov/ct2/show/NCT04895917

deleted-user

Det er en meget lille, men insisterende (!) kø, ved indgangen til Genmab i dag.

Bulder

Og de behøver ikke vise coronapas for at komme ind.

Bulder

US har helt skiftet farve. NBI mørkegrøn.