Genmab — Marts 2021
-
In the patient described, we also show that daratumumab therapy influenced the dynamics of several immunoregulatory cytokine levels (IL-6, IL-10, IL-17, IFN-γ, TNF-α, TGF-β) indicating an immunomodulatory effect of the drug beyond plasma cell depletion. In addition, we provide a literature review on the use of daratumumab in autoimmune conditions, including multi-treated and refractory patients with autoimmune hemolytic anemia (both CAD and warm forms), Evans syndrome (association of autoimmune
-
The Immunomodulatory Effect and Clinical Efficacy of Daratumumab in a Patient With Cold Agglutinin Disease. https://www.frontiersin.org/articles/10.3389/fimmu.2021.649441/full
-
Do you think Janssen with purpose will be holding back information regarding those programs as long as the royalty issue isn‘t settled?
-
They could. But also, the outcome of the arbitrage may determine what the best development path / way forward is for JNJ financially, they may decide to wait for that. Or they may use their development option for HexaCD38 as a pressure point in the arbitrage…
-
just look at Pfizer's Bourla. He said the company’s scientists and engineers gained a decade’s worth of experience in the past year working on the Covid-19 vaccine with Germany’s BioNTech SE , and is ready to pursue mRNA on its own. -ON ITS OWN he said. Screw BioNTech. https://www.wsj.com/articles/pfizer-goes-it-alone-to-expand-vaccine-business-beyond-covid-19-pandemic-11616491800
-
I understand the issue with hexacd38. But if it is significantly better than dara, they should follow that path. Just to fend off competition like Sarclisa, CAR-T and many other. Furthermore they would cut off HALO with a move to hexacd38...
-
No
-
Aktier/middag: Zealand og Norden tager teten i surt marked
-
Jeg har stillet spørgsmål til Jan ang Hexacd38 vs HALO. Så må vi se om Helge får plads til spørgsmålet
-
-
jeg ved ikke om den hr været vist før https://propatienter.dk/sygdomme/kraeft/lymfekraeft/3512-behandlingsrevolution-indenfor-lymfekraeft-vi-har-set-hvordan-tumorerne-pa-mindre-end-et-dogn-svandt-ind-og-blev-helt-blode-det-er-naermest-uvirkeligt.html?fbclid=IwAR17mbvEXXiU1bcst0GcynosgJF3CgfPHVcTkz_YtSKGlPtHF_TVexO9p7o
-
EL they should have a VERY god picture of that already when they compare thier preclinical PK models
Hello! It looks like you're interested in this conversation, but you don't have an account yet.
Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.
With your input, this post could be even better 💗
Tilmeld Log ind