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Genmab — Marts 2021

Planlagt Fastgjort Låst Flyttet Genmab
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  • G Offline
    G Offline
    GeorgeBest
    wrote on sidst redigeret af
    #1085

    I understand the issue with hexacd38. But if it is significantly better than dara, they should follow that path. Just to fend off competition like Sarclisa, CAR-T and many other. Furthermore they would cut off HALO with a move to hexacd38...

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #1086

      I agree, just saying they may wait with deciding that. And the longer they wait, the more development costs for Genmab.

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #1087

        and you are now assuming HexaCD38 will not need HALO, are you sure?

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        • G Offline
          G Offline
          GeorgeBest
          wrote on sidst redigeret af
          #1088

          No

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #1089

            neither do I. But I think we can rest assured that Genmab will do whatever they can to get this into SC themselves if possible lol

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            • Helge_LarsenPI-redaktørH Offline
              Helge_LarsenPI-redaktørH Offline
              Helge_LarsenPI-redaktør
              wrote on sidst redigeret af
              #1090

              Aktier/middag: Zealand og Norden tager teten i surt marked

              Just a moment...

              favicon

              (www.proinvestor.com)

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              • troldmandenT Offline
                troldmandenT Offline
                troldmanden
                wrote on sidst redigeret af
                #1091

                Jeg har stillet spørgsmål til Jan ang Hexacd38 vs HALO. Så må vi se om Helge får plads til spørgsmålet 🙂

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #1092

                  I doubt he'll be able to answer that, until they know what their optimal dose will be

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #1093

                    Health Canada approves Kesimpta® https://www.newswire.ca/news-releases/health-canada-approves-kesimpta-r-the-first-and-only-self-administered-targeted-b-cell-therapy-for-relapsing-remitting-multiple-sclerosis-rrms--853527292.html

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                    • I Offline
                      I Offline
                      ienk1
                      wrote on sidst redigeret af
                      #1094

                      jeg ved ikke om den hr været vist før https://propatienter.dk/sygdomme/kraeft/lymfekraeft/3512-behandlingsrevolution-indenfor-lymfekraeft-vi-har-set-hvordan-tumorerne-pa-mindre-end-et-dogn-svandt-ind-og-blev-helt-blode-det-er-naermest-uvirkeligt.html?fbclid=IwAR17mbvEXXiU1bcst0GcynosgJF3CgfPHVcTkz_YtSKGlPtHF_TVexO9p7o

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                      • troldmandenT Offline
                        troldmandenT Offline
                        troldmanden
                        wrote on sidst redigeret af
                        #1095

                        EL they should have a VERY god picture of that already when they compare thier preclinical PK models

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #1096

                          ienk1: Nej det er en ny (i øvrigt god baggrunds-)artikel, men vi havde forleden lidt debat om glofi vs epco pba en netop offentliggjort videnskabelig artikel, som også er nævnt i indledningen til dit link.

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #1097

                            Det er bl.a. Martin Hutchings begejstring for bispecifikke antistoffer, som gør at jeg tror på epco. Spørgsmålet er så, hvor stor en markedsandel epco vil kunne få.

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #1098

                              For konkurrence vil der blive.

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                              • G Offline
                                G Offline
                                GeorgeBest
                                wrote on sidst redigeret af
                                #1099

                                Bulder: har vi set noget konkret på om Roche vil udvikle en subcu version for Glofitamab?

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                                • BulderB Offline
                                  BulderB Offline
                                  Bulder
                                  wrote on sidst redigeret af
                                  #1100

                                  Ja: Robust development programmes are ongoing for mosunetuzumab and glofitamab, investigating the treatments as monotherapies and in combination with other molecules, as well as more convenient forms of administration such as subcutaneous administration, with several phase III trials planned in the near future.https://www.roche.com/media/releases/med-cor-2020-12-08.htm

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                                  • BulderB Offline
                                    BulderB Offline
                                    Bulder
                                    wrote on sidst redigeret af
                                    #1101

                                    Men epco kan jo komme først som sc.

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #1102

                                      troldmanden are you essentially saying they can estimate toxicity already in those preclinical models? (i can understand efficacy, but thought you would need it in human to find out how toxic it is?)

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                                      • troldmandenT Offline
                                        troldmandenT Offline
                                        troldmanden
                                        wrote on sidst redigeret af
                                        #1103

                                        We always need human trials. But its to closly related molecules, so there is a lot that can be compared in preclinical models vs dara clinical data

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                                        • troldmandenT Offline
                                          troldmandenT Offline
                                          troldmanden
                                          wrote on sidst redigeret af
                                          #1104

                                          two closely....

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