Genmab — Marts 2021

[GeorgeBest]

No

[E_L]

neither do I. But I think we can rest assured that Genmab will do whatever they can to get this into SC themselves if possible lol

[Helge_LarsenPI-redaktør]

Aktier/middag: Zealand og Norden tager teten i surt marked

Just a moment...

(www.proinvestor.com)

[troldmanden]

Jeg har stillet spørgsmål til Jan ang Hexacd38 vs HALO. Så må vi se om Helge får plads til spørgsmålet

[E_L]

I doubt he'll be able to answer that, until they know what their optimal dose will be

[E_L]

Health Canada approves Kesimpta https://www.newswire.ca/news-releases/health-canada-approves-kesimpta-r-the-first-and-only-self-administered-targeted-b-cell-therapy-for-relapsing-remitting-multiple-sclerosis-rrms--853527292.html

[ienk1]

jeg ved ikke om den hr været vist før https://propatienter.dk/sygdomme/kraeft/lymfekraeft/3512-behandlingsrevolution-indenfor-lymfekraeft-vi-har-set-hvordan-tumorerne-pa-mindre-end-et-dogn-svandt-ind-og-blev-helt-blode-det-er-naermest-uvirkeligt.html?fbclid=IwAR17mbvEXXiU1bcst0GcynosgJF3CgfPHVcTkz_YtSKGlPtHF_TVexO9p7o

[troldmanden]

EL they should have a VERY god picture of that already when they compare thier preclinical PK models

[Bulder]

ienk1: Nej det er en ny (i øvrigt god baggrunds-)artikel, men vi havde forleden lidt debat om glofi vs epco pba en netop offentliggjort videnskabelig artikel, som også er nævnt i indledningen til dit link.

[Bulder]

Det er bl.a. Martin Hutchings begejstring for bispecifikke antistoffer, som gør at jeg tror på epco. Spørgsmålet er så, hvor stor en markedsandel epco vil kunne få.

[Bulder]

For konkurrence vil der blive.

[GeorgeBest]

Bulder: har vi set noget konkret på om Roche vil udvikle en subcu version for Glofitamab?

[Bulder]

Ja: Robust development programmes are ongoing for mosunetuzumab and glofitamab, investigating the treatments as monotherapies and in combination with other molecules, as well as more convenient forms of administration such as subcutaneous administration, with several phase III trials planned in the near future.https://www.roche.com/media/releases/med-cor-2020-12-08.htm

[Bulder]

Men epco kan jo komme først som sc.

[E_L]

troldmanden are you essentially saying they can estimate toxicity already in those preclinical models? (i can understand efficacy, but thought you would need it in human to find out how toxic it is?)

[troldmanden]

We always need human trials. But its to closly related molecules, so there is a lot that can be compared in preclinical models vs dara clinical data

[troldmanden]

two closely....

[GeorgeBest]

14:13 @Bulder: men referencen til subcu kan jo være relateret til Mosunetuzumab, hvor vi har vist siden sidste efterår at Roche vil udvikle en subcu version

[Bulder]

Det kan være. Jeg ved ikke specifikt om glofi.

[E_L]

New smal trial - An Open Label Study to Evaluate Daratumumab in Participants With Moderate to Severe Systemic Lupus Erythematosus (DARALUP) https://clinicaltrials.gov/ct2/show/NCT04810754?term=genmab+OR+daratumumab+OR+darzalex+OR+ofatumumab+OR+Teprotumumab+OR+Tisotumab+OR+camidanlumab+OR+Enapotamab+OR+ADCT-301+OR+duobody+OR+hexabody+OR+Teclistamab+OR+Amivantamab+OR+Talquetamab+OR+Epcoritamab+OR+DuoHexabody&lupd_s=03%2F23%2F2021&draw=2&rank=1