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Genmab — Februar 2021

Planlagt Fastgjort Låst Flyttet Genmab
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  • JørgenVarnæsJ Offline
    JørgenVarnæsJ Offline
    JørgenVarnæs
    wrote on sidst redigeret af
    #145

    Det er måske epcoritamab, der er det primære program i det space? Umiddelbart mangler vi stadig PoC på hexa teknologien

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    • G Offline
      G Offline
      gentogen
      wrote on sidst redigeret af
      #146

      hexamerization-enhanced CD20 and CD37 antibodies cooperated in C1q binding and induced superior and synergistic complement-dependent cytotoxicity

      1 Reply Last reply
      0
      • G Offline
        G Offline
        gentogen
        wrote on sidst redigeret af
        #147

        Link Preview Image
        CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering - PubMed

        CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natural process of antibody hexamer formation on targete …

        favicon

        PubMed (pubmed.ncbi.nlm.nih.gov)

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        • JørgenVarnæsJ Offline
          JørgenVarnæsJ Offline
          JørgenVarnæs
          wrote on sidst redigeret af
          #148

          gad vide om det er en duo-hexa, de varmer op til der?

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          • JørgenVarnæsJ Offline
            JørgenVarnæsJ Offline
            JørgenVarnæs
            wrote on sidst redigeret af
            #149

            det kunne tyde på, at den rene hexcd20 ikke ligger i kortene

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            • S Offline
              S Offline
              Sukkeralf
              wrote on sidst redigeret af
              #150

              Genmab har jo sammen med Abbvie et hexaboostet CD37 BsAb, som evt kan kombineres med CD20 hvis alt falsker sig

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              • S Offline
                S Offline
                Sukkeralf
                wrote on sidst redigeret af
                #151

                Ofatumumab var i forvejen optimeret til at have bedre CDC end rituxan og det endte jo ikke så godt ud - og hexabody fremmer primært CDC, så nok derfor de ikke går den vej

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                • S Offline
                  S Offline
                  Sukkeralf
                  wrote on sidst redigeret af
                  #152

                  Desuden er CD20 området esktremt konkurrencepræget

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                  • P Offline
                    P Offline
                    peter12
                    wrote on sidst redigeret af
                    #153

                    Man må håbe at Hexa-cd38 ikke virker alt for godt heller, så der bliver sikkerheds issues

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                    0
                    • P Offline
                      P Offline
                      peter12
                      wrote on sidst redigeret af
                      #154

                      Webcastet var Morgan Stanley 15/9 men det er væk nu desværre

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                      0
                      • Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktør
                        wrote on sidst redigeret af
                        #155

                        God morgen. 🙂

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                        0
                        • Helge_LarsenPI-redaktørH Offline
                          Helge_LarsenPI-redaktørH Offline
                          Helge_LarsenPI-redaktør
                          wrote on sidst redigeret af
                          #156

                          Asien: Solide stigninger næsten overalt i regionen: https://www.proinvestor.com/investornyt/671857/asien-solide-stigninger-naesten-overalt-i-regionen

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                          • Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktør
                            wrote on sidst redigeret af
                            #157

                            Mandagens aviser med Carlsberg, Parken og Chr. Hansen: https://www.proinvestor.com/investornyt/671856/mandagens-aviser-med-carlsberg-parken-og-chr-hansen

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                            • P Offline
                              P Offline
                              Plimsoller
                              wrote on sidst redigeret af
                              #158

                              God morgen 🙂

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                              • StockBullS Offline
                                StockBullS Offline
                                StockBull
                                wrote on sidst redigeret af
                                #159

                                Genmab ligger stadig stabilt i trend kanalen fra Juni 2020 som indikere realistisk 12 mdr Genmab target 3000 kr https://nbg1.your-objectstorage.com/proinvestor-dev/forum/boards/90798_Interessandt_trend_fra_Juni_2020.JPG

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                                • K Offline
                                  K Offline
                                  Klarussen
                                  wrote on sidst redigeret af
                                  #160

                                  Og om 3 år?

                                  1 Reply Last reply
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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #161

                                    Treatment of Antibody-Mediated Post-Transplant Autoimmune-like Hepatitis with Daratumumab https://tct.confex.com/tct/2021/meetingapp.cgi/Paper/17519

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #162

                                      Conclusions

                                      Now 10 months post-HCT, the patient is off all hepatic supportive care and steroids have gradually been weaned. He remains negative for minimal residual disease and BCR-ABL fusion transcript and 100% donor chimerism. The dramatic response documented in this patient warrants further investigation of daratumumab for plasma cell-mediated autoimmune-like hepatitis in the post-transplant setting.

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #163

                                        Daratumumab Is Safe and Effective for the Treatment of Refractory Autoimmunity in Children https://tct.confex.com/tct/2021/meetingapp.cgi/Paper/17231

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                                        • V Offline
                                          V Offline
                                          Vitus
                                          wrote on sidst redigeret af
                                          #164

                                          Hvis Genmab skal nå i 3000 i løbet af 12 mdr, så skal den da snart til at lette...

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                                          0

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