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Genmab — Februar 2021

Planlagt Fastgjort Låst Flyttet Genmab
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  • G Offline
    G Offline
    gentogen
    wrote on sidst redigeret af
    #147

    Link Preview Image
    CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering - PubMed

    CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natural process of antibody hexamer formation on targete …

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    PubMed (pubmed.ncbi.nlm.nih.gov)

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    • JørgenVarnæsJ Offline
      JørgenVarnæsJ Offline
      JørgenVarnæs
      wrote on sidst redigeret af
      #148

      gad vide om det er en duo-hexa, de varmer op til der?

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      • JørgenVarnæsJ Offline
        JørgenVarnæsJ Offline
        JørgenVarnæs
        wrote on sidst redigeret af
        #149

        det kunne tyde på, at den rene hexcd20 ikke ligger i kortene

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        • S Offline
          S Offline
          Sukkeralf
          wrote on sidst redigeret af
          #150

          Genmab har jo sammen med Abbvie et hexaboostet CD37 BsAb, som evt kan kombineres med CD20 hvis alt falsker sig

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          • S Offline
            S Offline
            Sukkeralf
            wrote on sidst redigeret af
            #151

            Ofatumumab var i forvejen optimeret til at have bedre CDC end rituxan og det endte jo ikke så godt ud - og hexabody fremmer primært CDC, så nok derfor de ikke går den vej

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            • S Offline
              S Offline
              Sukkeralf
              wrote on sidst redigeret af
              #152

              Desuden er CD20 området esktremt konkurrencepræget

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              • P Offline
                P Offline
                peter12
                wrote on sidst redigeret af
                #153

                Man må håbe at Hexa-cd38 ikke virker alt for godt heller, så der bliver sikkerheds issues

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                • P Offline
                  P Offline
                  peter12
                  wrote on sidst redigeret af
                  #154

                  Webcastet var Morgan Stanley 15/9 men det er væk nu desværre

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                  • Helge_LarsenPI-redaktørH Offline
                    Helge_LarsenPI-redaktørH Offline
                    Helge_LarsenPI-redaktør
                    wrote on sidst redigeret af
                    #155

                    God morgen. 🙂

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                    • Helge_LarsenPI-redaktørH Offline
                      Helge_LarsenPI-redaktørH Offline
                      Helge_LarsenPI-redaktør
                      wrote on sidst redigeret af
                      #156

                      Asien: Solide stigninger næsten overalt i regionen: https://www.proinvestor.com/investornyt/671857/asien-solide-stigninger-naesten-overalt-i-regionen

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                      • Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktør
                        wrote on sidst redigeret af
                        #157

                        Mandagens aviser med Carlsberg, Parken og Chr. Hansen: https://www.proinvestor.com/investornyt/671856/mandagens-aviser-med-carlsberg-parken-og-chr-hansen

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                        • P Offline
                          P Offline
                          Plimsoller
                          wrote on sidst redigeret af
                          #158

                          God morgen 🙂

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                          • StockBullS Offline
                            StockBullS Offline
                            StockBull
                            wrote on sidst redigeret af
                            #159

                            Genmab ligger stadig stabilt i trend kanalen fra Juni 2020 som indikere realistisk 12 mdr Genmab target 3000 kr https://nbg1.your-objectstorage.com/proinvestor-dev/forum/boards/90798_Interessandt_trend_fra_Juni_2020.JPG

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                            • K Offline
                              K Offline
                              Klarussen
                              wrote on sidst redigeret af
                              #160

                              Og om 3 år?

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                              0
                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #161

                                Treatment of Antibody-Mediated Post-Transplant Autoimmune-like Hepatitis with Daratumumab https://tct.confex.com/tct/2021/meetingapp.cgi/Paper/17519

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #162

                                  Conclusions

                                  Now 10 months post-HCT, the patient is off all hepatic supportive care and steroids have gradually been weaned. He remains negative for minimal residual disease and BCR-ABL fusion transcript and 100% donor chimerism. The dramatic response documented in this patient warrants further investigation of daratumumab for plasma cell-mediated autoimmune-like hepatitis in the post-transplant setting.

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #163

                                    Daratumumab Is Safe and Effective for the Treatment of Refractory Autoimmunity in Children https://tct.confex.com/tct/2021/meetingapp.cgi/Paper/17231

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                                    • V Offline
                                      V Offline
                                      Vitus
                                      wrote on sidst redigeret af
                                      #164

                                      Hvis Genmab skal nå i 3000 i løbet af 12 mdr, så skal den da snart til at lette...

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                                      • K Offline
                                        K Offline
                                        Klarussen
                                        wrote on sidst redigeret af
                                        #165

                                        Tålmodighed er en dyd...

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                                        • B Offline
                                          B Offline
                                          bibob
                                          wrote on sidst redigeret af
                                          #166

                                          Vitus. Hvis Genmab letter allerede nu så er det 4000 du skal kigge efter. 😉

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