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Genmab — Februar 2021

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #97

    It is engineered to have two ‘Fab’ regions which bind to CD20, and one ‘Fab’ region which binds to CD3.

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    • BulderB Offline
      BulderB Offline
      Bulder
      wrote on sidst redigeret af
      #98

      Trispecific?

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      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #99

        I wonder if Genmab i working on something like this https://www.nature.com/articles/d41586-019-03495-3

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #100

          is

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #101

            they still call it a bispecific,2 mAb's

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #102

              https://www.genentechoncology.com/pipeline-molecules/glofitamab.html

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #103

                no, the one you refer to is from sanofi

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #104

                  It is probably two different epitopes on the same cd20 antigen then.

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                  • G Offline
                    G Offline
                    GeorgeBest
                    wrote on sidst redigeret af
                    #105

                    E L - therefore it looks like Roche is planning for Mosunetuzumab for first line and Glofitamab for later lines

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                    • G Offline
                      G Offline
                      GeorgeBest
                      wrote on sidst redigeret af
                      #106

                      and we know Jan want to put Epcoritamab in first line, and Epcoritamab is much more efficiant than Mosunetuzumab, therefore big advantage for Genmab

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #107

                        I am not sure whether they are different Bulder, looking at pictures the may just be constructed differently vis-a-vis the CD3

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                        • SolsenS Offline
                          SolsenS Offline
                          Solsen
                          wrote on sidst redigeret af
                          #108

                          Ingen nyheder med nu +17% i Seagen https://finance.yahoo.com/quote/SGEN?p=SGEN Besynderligt...

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                          • JørgenVarnæsJ Offline
                            JørgenVarnæsJ Offline
                            JørgenVarnæs
                            wrote on sidst redigeret af
                            #109

                            Jeg sidder også og roder efter nyheder. Mon der er noget M&A hurlumhej i beggrunden?

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                            • JørgenVarnæsJ Offline
                              JørgenVarnæsJ Offline
                              JørgenVarnæs
                              wrote on sidst redigeret af
                              #110

                              ...potential inclusion in s&p 500

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                              • JørgenVarnæsJ Offline
                                JørgenVarnæsJ Offline
                                JørgenVarnæs
                                wrote on sidst redigeret af
                                #111

                                Lidt anderledes end første gang GEN kom i C20 - dengang var reaktionen lodret ned og ud på røv og albuer...

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                                • Helge_LarsenPI-redaktørH Offline
                                  Helge_LarsenPI-redaktørH Offline
                                  Helge_LarsenPI-redaktør
                                  wrote on sidst redigeret af
                                  #112

                                  God morgen. 🙂

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                                  • H Offline
                                    H Offline
                                    Hevis
                                    wrote on sidst redigeret af
                                    #113

                                    Ser på LinkedIn at Genmab søger Director til Epcoritamab

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #114

                                      Meg Tirrell
                                      @megtirrell

                                      A deep dive into the effect of the Defense Production Act on a rare disease drug, Horizon’s Tepezza, for thyroid eye disease, and the impact it’s had on patients as manufacturing lines were diverted to a #covid19 vaccine https://twitter.com/megtirrell/status/1357851653152641024

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                                      • troldmandenT Offline
                                        troldmandenT Offline
                                        troldmanden
                                        wrote on sidst redigeret af
                                        #115

                                        Jan fortalte allerede for flere år siden at Jansen havde over 400 ansatte der arbejde fuld tid med dara. Det var inden den blev lanceret. Så der venter en meget kraftig stigning i antal ansatte hos genmab de næste 24 mdr (nu løfter Abb heldigvis også en stor del af det, men der kommer ikke til at gå så lang tid inden de runder 1000 ansatte)

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                                        • SolsenS Offline
                                          SolsenS Offline
                                          Solsen
                                          wrote on sidst redigeret af
                                          #116

                                          Genmab hader sikkert også minusrenter - pengene i arbejde giver bedre afkast 😉

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