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Genmab — Februar 2021

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #93

    true

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #94

      actually, re-reading that comment, I know realise they may be talking about Glofitamab when they say 2:1; so I
      looked it up:

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #95

        *now

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #96

          Glofitamab is an investigational CD20xCD3 T-cell engaging bispecific antibody designed to target CD20 on the surface of B-cells and CD3 on the surface of T-cells. This dual targeting activates and redirects a patient’s existing T-cells to engage and eliminate target B-cells by releasing cytotoxic proteins into the B-cells. Glofi is based on a novel structural format which we call ‘2:1’, which refers to the structure of the antibody.

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #97

            It is engineered to have two ‘Fab’ regions which bind to CD20, and one ‘Fab’ region which binds to CD3.

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #98

              Trispecific?

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #99

                I wonder if Genmab i working on something like this https://www.nature.com/articles/d41586-019-03495-3

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #100

                  is

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #101

                    they still call it a bispecific,2 mAb's

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #102

                      https://www.genentechoncology.com/pipeline-molecules/glofitamab.html

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #103

                        no, the one you refer to is from sanofi

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #104

                          It is probably two different epitopes on the same cd20 antigen then.

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                          • G Offline
                            G Offline
                            GeorgeBest
                            wrote on sidst redigeret af
                            #105

                            E L - therefore it looks like Roche is planning for Mosunetuzumab for first line and Glofitamab for later lines

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                            • G Offline
                              G Offline
                              GeorgeBest
                              wrote on sidst redigeret af
                              #106

                              and we know Jan want to put Epcoritamab in first line, and Epcoritamab is much more efficiant than Mosunetuzumab, therefore big advantage for Genmab

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #107

                                I am not sure whether they are different Bulder, looking at pictures the may just be constructed differently vis-a-vis the CD3

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                                • SolsenS Offline
                                  SolsenS Offline
                                  Solsen
                                  wrote on sidst redigeret af
                                  #108

                                  Ingen nyheder med nu +17% i Seagen https://finance.yahoo.com/quote/SGEN?p=SGEN Besynderligt...

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                                  • JørgenVarnæsJ Offline
                                    JørgenVarnæsJ Offline
                                    JørgenVarnæs
                                    wrote on sidst redigeret af
                                    #109

                                    Jeg sidder også og roder efter nyheder. Mon der er noget M&A hurlumhej i beggrunden?

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                                    • JørgenVarnæsJ Offline
                                      JørgenVarnæsJ Offline
                                      JørgenVarnæs
                                      wrote on sidst redigeret af
                                      #110

                                      ...potential inclusion in s&p 500

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                                      • JørgenVarnæsJ Offline
                                        JørgenVarnæsJ Offline
                                        JørgenVarnæs
                                        wrote on sidst redigeret af
                                        #111

                                        Lidt anderledes end første gang GEN kom i C20 - dengang var reaktionen lodret ned og ud på røv og albuer...

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                                        • Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktør
                                          wrote on sidst redigeret af
                                          #112

                                          God morgen. 🙂

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