Genmab — December 2020
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Helge, er Epco på søndag ikke kl 21.30 da tid? 9.30 ville jo være midt om natten PST. Ikke fordi tidspunktet er afgørende, da der vist ikke er offentlig adgang, men vi skal nok ikke forvente kommentarer på Twitter eller en youtube-version før sent om aftenen.
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Sanofi kører et studie i Isatuximab + Cemiplimab mod bl.a. NSCLC. Winkel har tidligere sagt, at de vil afvente resultater fra dette studie, før der tages stilling til en evt. genoptagelse af daratumumab i solide.
https://www.clinicaltrials.gov/ct2/show/NCT03367819?term=isatuximab+solid+tumor&draw=2&rank=1 -
Jeg ved ikke om dette har været linket før https://clincancerres.aacrjournals.org/content/26/9/2203
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JNJ-7957 er det samme som teclistamab. peter's link er det prækliniske studie, som har ført videre til klinisk studie i dara+teclistamab i MM https://www.clinicaltrials.gov/ct2/show/NCT04108195?term=daratumumab+teclistamab&draw=2&rank=1
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Var det leukemi udover MM som de ville afprøve hexa-cd38 imod?
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Fra aftalen med Janssen: HexaBody-CD38 could be superior to daratumumab for certain tumor cell types and may expand and extend the promise of CD38-targeted therapies for more patients with multiple myeloma, lymphoma, leukemia, and potentially beyond.
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Ja klart
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Dr Mark Wildgust: Updated APOLLO Trial Results Confirm Daratumumab Safety in Multiple Myeloma https://www.ajmc.com/view/dr-mark-wildgust-updated-apollo-trial-results-confirm-daratumumab-safety-in-multiple-myeloma - ONLY
5% of patients had infusion-related reactions in the APOLLO study, and all of those were grade 1/grade 2. So real confirmation that subcu dara is well tolerated. -
https://genmab-at-ash-2020.com/ genmab-at-ash-2020
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a bit strange when you look at the pipeline, poster on the right or https://virtualboothdemo.s3.amazonaws.com/Genmab/Content/PDFs/ash/I FINAL PIPELINE.pdf , it shows HexaBody CD38 in development phase I/II
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