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Genmab — Oktober 2020

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #371

    But on the other hand Jan have been so optimistic and emphasized the fact that they have been able to dose escalate quickly

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    • G Offline
      G Offline
      GeorgeBest
      wrote on sidst redigeret af
      #372

      At least the liver tox was not so serious that FDA put a hold on GEN1046 (what FDA did on DR5/DR5)

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      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #373

        And all liver issues were grade 3 or less, and grade 3 could be handled with steroids.

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        • G Offline
          G Offline
          GeorgeBest
          wrote on sidst redigeret af
          #374

          Maybe a satisfactory efficacy can be reached with rather small doses, and therefore problem might be solved...

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #375

            MTD was not reached.

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #376

              ok. my thinking was like Bulder; we knew liver would be point of focus and it seems to be manageable, so i took it as a positive

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #377

                to be continued in november...

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                • S Offline
                  S Offline
                  Sukkeralf
                  wrote on sidst redigeret af
                  #378

                  Yes - we need to see more detailed data and fingers crossed until then

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                  • SvingtraderenS Offline
                    SvingtraderenS Offline
                    Svingtraderen
                    wrote on sidst redigeret af
                    #379

                    Genmab: Medwatch, https://medwatch.dk/Medicinal___Biotek/article12492112.ece?utm_source=Feed&utm_medium=latest

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                    • DarvinD Offline
                      DarvinD Offline
                      Darvin
                      wrote on sidst redigeret af
                      #380

                      Bulder - nævnte det samme da det blev offentliggjort, men det blev skudt ned herinde 😉 Hvis! - så skal vi kigge grundigt over skulderen for at skimte 3.000 🙂

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                      • SolsenS Offline
                        SolsenS Offline
                        Solsen
                        wrote on sidst redigeret af
                        #381

                        I de tal vi så kan vi kun konkludere at stoffet her en effekt. I november bliver der klart, hvor godt stoffet er -;)

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                        • SEACOPS Offline
                          SEACOPS Offline
                          SEACOP
                          wrote on sidst redigeret af
                          #382

                          Donation givet med stor tak.

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                          • SEACOPS Offline
                            SEACOPS Offline
                            SEACOP
                            wrote on sidst redigeret af
                            #383

                            Just a moment...

                            favicon

                            (proinvestor.com)

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                            • Helge_LarsenPI-redaktørH Offline
                              Helge_LarsenPI-redaktørH Offline
                              Helge_LarsenPI-redaktør
                              wrote on sidst redigeret af
                              #384

                              Tusinde tak SEACOP. 🙂

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #385

                                I noticed on this Korean site -which is part of the Ministry of Food and Drug Safety- a refecence to Epcoritamab, which, upon translating reads "Randomized, open-label, phase 3 clinical trial comparing epcoritamab with investigator-selected chemotherapy in relapsed/refractory diffuse large B-cell lymphoma"

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #386

                                  https://nedrug.mfds.go.kr/pbp/CCBBC01

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #387

                                    Jan earlier hinted that a Ph 3 could be started this year...

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #388

                                      Caveat: I don't speak Korean, using google translate, AND the company doing it is IQvia Korea instead of Genmab or AbbVie

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #389

                                        IQvia is a Data Science company, I know they deal with AbbVie, I don't know if they also provide assistence in trial management ? https://www.iqvia.com/blogs/2020/02/will-virtual-trials-be-the-end-of-investigator-sites

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                                        • G Offline
                                          G Offline
                                          GeorgeBest
                                          wrote on sidst redigeret af
                                          #390

                                          Thank you E L. Jan mentioned at the latest fireside chat, that epcoritamab could potentially eleminate chemotherapy. This might be one of the steps to prove that...

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