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Genmab — Oktober 2020

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • G Offline
    G Offline
    GeorgeBest
    wrote on sidst redigeret af
    #372

    At least the liver tox was not so serious that FDA put a hold on GEN1046 (what FDA did on DR5/DR5)

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    • BulderB Offline
      BulderB Offline
      Bulder
      wrote on sidst redigeret af
      #373

      And all liver issues were grade 3 or less, and grade 3 could be handled with steroids.

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      • G Offline
        G Offline
        GeorgeBest
        wrote on sidst redigeret af
        #374

        Maybe a satisfactory efficacy can be reached with rather small doses, and therefore problem might be solved...

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #375

          MTD was not reached.

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #376

            ok. my thinking was like Bulder; we knew liver would be point of focus and it seems to be manageable, so i took it as a positive

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #377

              to be continued in november...

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              • S Offline
                S Offline
                Sukkeralf
                wrote on sidst redigeret af
                #378

                Yes - we need to see more detailed data and fingers crossed until then

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                • SvingtraderenS Offline
                  SvingtraderenS Offline
                  Svingtraderen
                  wrote on sidst redigeret af
                  #379

                  Genmab: Medwatch, https://medwatch.dk/Medicinal___Biotek/article12492112.ece?utm_source=Feed&utm_medium=latest

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                  • DarvinD Offline
                    DarvinD Offline
                    Darvin
                    wrote on sidst redigeret af
                    #380

                    Bulder - nævnte det samme da det blev offentliggjort, men det blev skudt ned herinde 😉 Hvis! - så skal vi kigge grundigt over skulderen for at skimte 3.000 🙂

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                    • SolsenS Offline
                      SolsenS Offline
                      Solsen
                      wrote on sidst redigeret af
                      #381

                      I de tal vi så kan vi kun konkludere at stoffet her en effekt. I november bliver der klart, hvor godt stoffet er -;)

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                      • SEACOPS Offline
                        SEACOPS Offline
                        SEACOP
                        wrote on sidst redigeret af
                        #382

                        Donation givet med stor tak.

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                        • SEACOPS Offline
                          SEACOPS Offline
                          SEACOP
                          wrote on sidst redigeret af
                          #383

                          Just a moment...

                          favicon

                          (proinvestor.com)

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                          • Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktør
                            wrote on sidst redigeret af
                            #384

                            Tusinde tak SEACOP. 🙂

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #385

                              I noticed on this Korean site -which is part of the Ministry of Food and Drug Safety- a refecence to Epcoritamab, which, upon translating reads "Randomized, open-label, phase 3 clinical trial comparing epcoritamab with investigator-selected chemotherapy in relapsed/refractory diffuse large B-cell lymphoma"

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #386

                                https://nedrug.mfds.go.kr/pbp/CCBBC01

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #387

                                  Jan earlier hinted that a Ph 3 could be started this year...

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #388

                                    Caveat: I don't speak Korean, using google translate, AND the company doing it is IQvia Korea instead of Genmab or AbbVie

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #389

                                      IQvia is a Data Science company, I know they deal with AbbVie, I don't know if they also provide assistence in trial management ? https://www.iqvia.com/blogs/2020/02/will-virtual-trials-be-the-end-of-investigator-sites

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                                      • G Offline
                                        G Offline
                                        GeorgeBest
                                        wrote on sidst redigeret af
                                        #390

                                        Thank you E L. Jan mentioned at the latest fireside chat, that epcoritamab could potentially eleminate chemotherapy. This might be one of the steps to prove that...

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                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #391

                                          and this link seems to indicate that Amivantamab has entered a breakthrough therapy program in China https://xueqiu.com/8965749698/161088590

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