Skip to content
  • Debatforum
  • Seneste
  • Populære
  • Bruger
Temaer
  • Light
  • Dark

Kollaps
FORSIDEN
Log ind Opret konto

Genmab — Oktober 2020

Planlagt Fastgjort Låst Flyttet Genmab
767 Indlæg 1 Posters 0 Visninger
  • Ældste til nyeste
  • Nyeste til ældste
  • Most Votes
Svar
  • Svar som emne
Login for at svare
Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #370

    I kind of feel the same as Nordea - efficacy looks promissing but a little worried about the liver tox that was what we needed to avoid so hope that we do not end up in a story like DR5/DR5.

    1 Reply Last reply
    0
    • S Offline
      S Offline
      Sukkeralf
      wrote on sidst redigeret af
      #371

      But on the other hand Jan have been so optimistic and emphasized the fact that they have been able to dose escalate quickly

      1 Reply Last reply
      0
      • G Offline
        G Offline
        GeorgeBest
        wrote on sidst redigeret af
        #372

        At least the liver tox was not so serious that FDA put a hold on GEN1046 (what FDA did on DR5/DR5)

        1 Reply Last reply
        0
        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #373

          And all liver issues were grade 3 or less, and grade 3 could be handled with steroids.

          1 Reply Last reply
          0
          • G Offline
            G Offline
            GeorgeBest
            wrote on sidst redigeret af
            #374

            Maybe a satisfactory efficacy can be reached with rather small doses, and therefore problem might be solved...

            1 Reply Last reply
            0
            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #375

              MTD was not reached.

              1 Reply Last reply
              0
              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #376

                ok. my thinking was like Bulder; we knew liver would be point of focus and it seems to be manageable, so i took it as a positive

                1 Reply Last reply
                0
                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #377

                  to be continued in november...

                  1 Reply Last reply
                  0
                  • S Offline
                    S Offline
                    Sukkeralf
                    wrote on sidst redigeret af
                    #378

                    Yes - we need to see more detailed data and fingers crossed until then

                    1 Reply Last reply
                    0
                    • SvingtraderenS Offline
                      SvingtraderenS Offline
                      Svingtraderen
                      wrote on sidst redigeret af
                      #379

                      Genmab: Medwatch, https://medwatch.dk/Medicinal___Biotek/article12492112.ece?utm_source=Feed&utm_medium=latest

                      1 Reply Last reply
                      0
                      • DarvinD Offline
                        DarvinD Offline
                        Darvin
                        wrote on sidst redigeret af
                        #380

                        Bulder - nævnte det samme da det blev offentliggjort, men det blev skudt ned herinde 😉 Hvis! - så skal vi kigge grundigt over skulderen for at skimte 3.000 🙂

                        1 Reply Last reply
                        0
                        • SolsenS Offline
                          SolsenS Offline
                          Solsen
                          wrote on sidst redigeret af
                          #381

                          I de tal vi så kan vi kun konkludere at stoffet her en effekt. I november bliver der klart, hvor godt stoffet er -;)

                          1 Reply Last reply
                          0
                          • SEACOPS Offline
                            SEACOPS Offline
                            SEACOP
                            wrote on sidst redigeret af
                            #382

                            Donation givet med stor tak.

                            1 Reply Last reply
                            0
                            • SEACOPS Offline
                              SEACOPS Offline
                              SEACOP
                              wrote on sidst redigeret af
                              #383

                              Just a moment...

                              favicon

                              (proinvestor.com)

                              1 Reply Last reply
                              0
                              • Helge_LarsenPI-redaktørH Offline
                                Helge_LarsenPI-redaktørH Offline
                                Helge_LarsenPI-redaktør
                                wrote on sidst redigeret af
                                #384

                                Tusinde tak SEACOP. 🙂

                                1 Reply Last reply
                                0
                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #385

                                  I noticed on this Korean site -which is part of the Ministry of Food and Drug Safety- a refecence to Epcoritamab, which, upon translating reads "Randomized, open-label, phase 3 clinical trial comparing epcoritamab with investigator-selected chemotherapy in relapsed/refractory diffuse large B-cell lymphoma"

                                  1 Reply Last reply
                                  0
                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #386

                                    https://nedrug.mfds.go.kr/pbp/CCBBC01

                                    1 Reply Last reply
                                    0
                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #387

                                      Jan earlier hinted that a Ph 3 could be started this year...

                                      1 Reply Last reply
                                      0
                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #388

                                        Caveat: I don't speak Korean, using google translate, AND the company doing it is IQvia Korea instead of Genmab or AbbVie

                                        1 Reply Last reply
                                        0
                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #389

                                          IQvia is a Data Science company, I know they deal with AbbVie, I don't know if they also provide assistence in trial management ? https://www.iqvia.com/blogs/2020/02/will-virtual-trials-be-the-end-of-investigator-sites

                                          1 Reply Last reply
                                          0

                                          Hello! It looks like you're interested in this conversation, but you don't have an account yet.

                                          Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.

                                          With your input, this post could be even better 💗

                                          Tilmeld Log ind

                                          • Log ind

                                          • Har du ikke en konto? Tilmeld

                                          • Login or register to search.
                                          • First post
                                            Last post
                                          0
                                          • Debatforum
                                          • Seneste
                                          • Populære
                                          • Bruger