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Genmab — Juni 2020

Planlagt Fastgjort Låst Flyttet Genmab
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  • G Offline
    G Offline
    gentogen
    wrote on sidst redigeret af
    #368

    Mim8 was capable of normalizing thrombin generation and blood clot formation, respectively, with approximately 15 times greater potency than emicizumab

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    • G Offline
      G Offline
      gentogen
      wrote on sidst redigeret af
      #369

      A similar potency improvement was demonstrated in a tail vein transection bleeding model in FVIII-deficient mice

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      0
      • G Offline
        G Offline
        gentogen
        wrote on sidst redigeret af
        #370

        Just a moment...

        favicon

        (ashpublications.org)

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #371

          Medicinrådet: Det er en fordel for patienterne, at emicizumab kan administreres som subkutan injektion hver uge, hver
          anden eller hver fjerde uge sammenlignet med standard FVIII- og EHL-præparater, der administreres som
          intravenøs infusion flere gange om ugen. https://medicinraadet.dk/media/yr2czsxb/medicinraadets-vurdering-af-klinisk-merværdi-vedr-emicizumab-til-haemofili-a-vers-1-0_adlegacy.pdf side 16

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #372

            Hvis så ydermere mim8 kan gives i "small volumes in a pen device". Peger det på yderligere fordele i form af hjemmeadministration.

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #373

              Plus "15 times greater potency".

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #374

                @roldmanden without more information it is hard to judge if it is bad news or just a delay ; in every review there will be interaction between both parties & additional questions asked by the FDA, mabye it just went slower due to time constraints (which the FDA have recently indicated could happen) we just don't know (yet?)

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #375

                  Let's hope they don't @royal ; even if they do, they will never admit it, but the first thing I thought when I heard about Novartis' problems with the FDA last year was 'I hope that doesn't impact Ofa..." (but i can be a bit cynical sometimes 😉 )

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #376

                    Epcoritamab på dansk ("lovende"): https://haematologisktidsskrift.dk/sygdomme/lymfoma/720-subkutant-bispecifikt-cd3-cd20-antistof-mulig-konkurrent-til-car-t.html

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                    • Helge_LarsenPI-redaktørH Offline
                      Helge_LarsenPI-redaktørH Offline
                      Helge_LarsenPI-redaktør
                      wrote on sidst redigeret af
                      #377

                      Tusinde tak Bulder for en rigtig god artikel. Jeg har den i debatten. 🙂

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                      0
                      • Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktør
                        wrote on sidst redigeret af
                        #378

                        lagt

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                        • B Offline
                          B Offline
                          BioShare
                          wrote on sidst redigeret af
                          #379

                          Super artikel Bulder...tak, det lyder virkelig lovende. Spændende at følge i forhold til CAR-T. “Lige så effektiv...og mere sikker”.

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                          0
                          • L Offline
                            L Offline
                            lahn1
                            wrote on sidst redigeret af
                            #380

                            Det lyder lovende, Bulder

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                            • T Offline
                              T Offline
                              transalp
                              wrote on sidst redigeret af
                              #381

                              Go morgen og tak for god læsning der, bulder.. 🙂

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                              0
                              • G Offline
                                G Offline
                                GeorgeBest
                                wrote on sidst redigeret af
                                #382

                                Er der ny udvikling omkring dara i Alzheimer? https://twitter.com/ej23ny/status/1268741226477559809?s=21

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                                • G Offline
                                  G Offline
                                  GeorgeBest
                                  wrote on sidst redigeret af
                                  #383

                                  ClinicalTrials.gov

                                  favicon

                                  (clinicaltrials.gov)

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                                  • G Offline
                                    G Offline
                                    GeorgeBest
                                    wrote on sidst redigeret af
                                    #384

                                    https://twitter.com/ej23ny/status/1268752935196012550?s=21

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                                    • B Offline
                                      B Offline
                                      bibob
                                      wrote on sidst redigeret af
                                      #385

                                      God morgen. :-). Og tak Bulder for en god artikel. Også tak GB for nyt . Lyder spændende.

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #386

                                        Nice volume pick up in US recently

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                                        0
                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #387

                                          Volume in Mio: Copenhagen (shares) vs US (ADS; factor x10)

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                                          0

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