Genmab — Juni 2020

[gentogen]

Det med de 15 gange bedre Mim-8 stammer fra; "Mim8 - a Next-Generation FVIII Mimetic Bi-Specific Antibody - Potently Restores the Hemostatic Capacity in Hemophilia a Settings in Vitro and In Vivo"

[gentogen]

Mim8 was capable of normalizing thrombin generation and blood clot formation, respectively, with approximately 15 times greater potency than emicizumab

[gentogen]

A similar potency improvement was demonstrated in a tail vein transection bleeding model in FVIII-deficient mice

[gentogen]

Just a moment...

(ashpublications.org)

[Bulder]

Medicinrådet: Det er en fordel for patienterne, at emicizumab kan administreres som subkutan injektion hver uge, hver
anden eller hver fjerde uge sammenlignet med standard FVIII- og EHL-præparater, der administreres som
intravenøs infusion flere gange om ugen. https://medicinraadet.dk/media/yr2czsxb/medicinraadets-vurdering-af-klinisk-merværdi-vedr-emicizumab-til-haemofili-a-vers-1-0_adlegacy.pdf side 16

[Bulder]

Hvis så ydermere mim8 kan gives i "small volumes in a pen device". Peger det på yderligere fordele i form af hjemmeadministration.

[Bulder]

Plus "15 times greater potency".

[E_L]

@roldmanden without more information it is hard to judge if it is bad news or just a delay ; in every review there will be interaction between both parties & additional questions asked by the FDA, mabye it just went slower due to time constraints (which the FDA have recently indicated could happen) we just don't know (yet?)

[E_L]

Let's hope they don't @royal ; even if they do, they will never admit it, but the first thing I thought when I heard about Novartis' problems with the FDA last year was 'I hope that doesn't impact Ofa..." (but i can be a bit cynical sometimes )

[Bulder]

Epcoritamab på dansk ("lovende"): https://haematologisktidsskrift.dk/sygdomme/lymfoma/720-subkutant-bispecifikt-cd3-cd20-antistof-mulig-konkurrent-til-car-t.html

[Helge_LarsenPI-redaktør]

Tusinde tak Bulder for en rigtig god artikel. Jeg har den i debatten.

[Helge_LarsenPI-redaktør]

lagt

[BioShare]

Super artikel Bulder...tak, det lyder virkelig lovende. Spændende at følge i forhold til CAR-T. “Lige så effektiv...og mere sikker”.

[lahn1]

Det lyder lovende, Bulder

[transalp]

Go morgen og tak for god læsning der, bulder..

[GeorgeBest]

Er der ny udvikling omkring dara i Alzheimer? https://twitter.com/ej23ny/status/1268741226477559809?s=21

[GeorgeBest]

ClinicalTrials.gov

(clinicaltrials.gov)

[GeorgeBest]

https://twitter.com/ej23ny/status/1268752935196012550?s=21

[bibob]

God morgen. :-). Og tak Bulder for en god artikel. Også tak GB for nyt . Lyder spændende.

[E_L]

Nice volume pick up in US recently