Genmab — Maj 2020

[GeorgeBest]

Mindre bivirkninger ved SC bør vel også betyde noget...

[Bulder]

Hvis pts kan vælge, vil de vælge sc pga færre IR og bekvemmeligheden. Hvis lægerne kan vælge, vil de vælge sc pga færre IR. Hvis klinikkerne/hospitalerne kan vælge, vil de vælge sc pga større gennemstrømning og fleksibilitet = bedre økonomi. Hvis forsikringsselskaberne kan vælge, vil de vælge sc pga de lavere omkostninger qua den kortere opholdstid.

[E_L]

in summary: everyone will choose SC?

[E_L]

from that earlier JNJ link: "Based on its favorable profile, we are
accelerating the development of DARZALEX FASPRO"

[Bulder]

Markedsføringen bliver en udfordring, siger JnJ. Ingen face to face i denne tid. Det bliver virtuelt det hele. Vi vil i den kommende tid se en strøm af instruktions-videoer på u-tube, hvor sygeplejersker instrueres i håndteringen af stoffet.

[E_L]

this Dr. Suzanne Lentzsch
@SLentzsch tweets
Reduced volume per Daratumumab infusion will be especially important for AL amyloidosis patients with cardiac involvement

[peter12]

Det må være nemt at overtale patienterne til at blive hjemme og få en sygeplejerske på besøg i stedet, med dara sc ? Tror det vil sælge godt

[peter12]

I disse tider med CV19

[E_L]

i asked on twitter a week ago : Do you think that could mean Dara SC could be home administered after the first few doses?

[E_L]

A: Jonathan Kaufman, MD
@kaufman_MMdoc

Well, we haven’t done it with velcade yet and that’s administered over several seconds.
Ben Derman
@bdermanmd

Also tougher because dara sq is higher volume injection which makes it tougher to do than bortezomib.

[peter12]

I think Jan had the question some time in our qa, and answered like that ?

[E_L]

yes, Jan does not see that happen (yet )

[E_L]

but: "Under pressure everything becomes fluid" .
So keep asking

[peter12]

Bulder: About sc dara: Will home administration by a nurse be possible? And will self administration be possible - like insulin injections?
Jan:We believe that a nurse or other healthcare professional will be essential to inject the SubCu Daratumumab formulation, because of the high amount of protein https://nbg1.your-objectstorage.com/proinvestor-dev/forum/ir/cms/QA-Genmab 2018-11-21.pdf

[E_L]

well, if you read it back like that, i would not exclude home administration with a nurse coming to your home. I think Bulder has asked it anohter time also, with a more negative answer @Bulder ?

[peter12]

Maybe the insurance for the car AND
content will make it impossible

[E_L]

yes, i really had not thought of that price/safety issue until Mcjean mentioned it yesterday lol

[Bulder]

I've just asked my sister (who has been US-nurse all her life), if they have a system with home-nurses in the USA just like we have in DK. Awaiting her answer. I don't think we shall expect self-administration.

[nohope]

In NY/USA 88 % of all patients who went to ICU died. This is a very high percentage - because ? Well, if you get a patient with Covid-19 and he dies you will be paid 19.000,- USD but if you get a patient and give him ICU the you get 39.000 USD. Hospitals in US are supposed to make money, the more the better, so they will always make the choice which gives the most to the hospital.

[nohope]

If pricing is not in favour of the profit for the hospital - then you can forget about sc being used.