Genmab — Maj 2020

[GeorgeBest]

Enig transalp, men lidt spøjs hvordan det system fungerer

[bibob]

Mon ikke de ( forsikringsselskaberne ) vil vælge sc pga. den kortere behandlingstid. Det må jo alt andet lige være dyrere med den timelange IV infusion. Også selv om IV måske er billigere i indkøb. ??

[nohope]

Jeg har tidligere spurgt om økonomien i sc vs IV uden at få svar. Hvis sc vælges er medicinprisen utvivlsomt højere,mens hospitalerne får mindre. Derfor kan IV være valget hvis hospitalerne kan vælge frit.

[GeorgeBest]

Mindre bivirkninger ved SC bør vel også betyde noget...

[Bulder]

Hvis pts kan vælge, vil de vælge sc pga færre IR og bekvemmeligheden. Hvis lægerne kan vælge, vil de vælge sc pga færre IR. Hvis klinikkerne/hospitalerne kan vælge, vil de vælge sc pga større gennemstrømning og fleksibilitet = bedre økonomi. Hvis forsikringsselskaberne kan vælge, vil de vælge sc pga de lavere omkostninger qua den kortere opholdstid.

[E_L]

in summary: everyone will choose SC?

[E_L]

from that earlier JNJ link: "Based on its favorable profile, we are
accelerating the development of DARZALEX FASPRO"

[Bulder]

Markedsføringen bliver en udfordring, siger JnJ. Ingen face to face i denne tid. Det bliver virtuelt det hele. Vi vil i den kommende tid se en strøm af instruktions-videoer på u-tube, hvor sygeplejersker instrueres i håndteringen af stoffet.

[E_L]

this Dr. Suzanne Lentzsch
@SLentzsch tweets
Reduced volume per Daratumumab infusion will be especially important for AL amyloidosis patients with cardiac involvement

[peter12]

Det må være nemt at overtale patienterne til at blive hjemme og få en sygeplejerske på besøg i stedet, med dara sc ? Tror det vil sælge godt

[peter12]

I disse tider med CV19

[E_L]

i asked on twitter a week ago : Do you think that could mean Dara SC could be home administered after the first few doses?

[E_L]

A: Jonathan Kaufman, MD
@kaufman_MMdoc

Well, we haven’t done it with velcade yet and that’s administered over several seconds.
Ben Derman
@bdermanmd

Also tougher because dara sq is higher volume injection which makes it tougher to do than bortezomib.

[peter12]

I think Jan had the question some time in our qa, and answered like that ?

[E_L]

yes, Jan does not see that happen (yet )

[E_L]

but: "Under pressure everything becomes fluid" .
So keep asking

[peter12]

Bulder: About sc dara: Will home administration by a nurse be possible? And will self administration be possible - like insulin injections?
Jan:We believe that a nurse or other healthcare professional will be essential to inject the SubCu Daratumumab formulation, because of the high amount of protein https://nbg1.your-objectstorage.com/proinvestor-dev/forum/ir/cms/QA-Genmab 2018-11-21.pdf

[E_L]

well, if you read it back like that, i would not exclude home administration with a nurse coming to your home. I think Bulder has asked it anohter time also, with a more negative answer @Bulder ?

[peter12]

Maybe the insurance for the car AND
content will make it impossible

[E_L]

yes, i really had not thought of that price/safety issue until Mcjean mentioned it yesterday lol