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Genmab — Februar 2020

Planlagt Fastgjort Låst Flyttet Genmab
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  • Helge_LarsenPI-redaktørH Offline
    Helge_LarsenPI-redaktørH Offline
    Helge_LarsenPI-redaktør
    wrote on sidst redigeret af
    #129

    5 år JKY. 😉

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    • J Offline
      J Offline
      JKY_VH
      wrote on sidst redigeret af
      #130

      som tiden dog går Helge:-)

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      • Legolas23L Offline
        Legolas23L Offline
        Legolas23
        wrote on sidst redigeret af
        #131

        Jeg ser det som sektor rotation pga coronavirusen væk fra berørte sektorer til bla medicinal. Jeg ser ingen hokus pokus i det. Der vil komme bump, korrektioner og andre besværligheder, men jeg er på ingen måder urolig.

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #132

          Durable response of multiple myeloma and non‐small cell lung cancer with simultaneous, biologically targeted treatment https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.16393

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #133

            Thx E L. "Whether CD38 blockade on the lung tumour cells through daratumumab may have enhanced cytotoxic T‐cell function and contributed to the excellent response of the NSCLC to pembrolizumab, as recently reported for an in‐vivo model of lung cancer, is unknown (Chen et al., 2018)." But the idea is still alive.

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #134

              glad someone always reads these 😉

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #135

                Interesting that nsclc responded to pembro despite given dex as well. I wonder whether they should have chosen pembro in stead of atezo in the solid trial back then. Blocking PD-1 in stead of PD-L1?

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                • Legolas23L Offline
                  Legolas23L Offline
                  Legolas23
                  wrote on sidst redigeret af
                  #136

                  Hvem ejer pembro. Også BMS?

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #137

                    Maybe, but remember that the Pembro/Dara trial in MM was withdrawn a while back

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #138

                      Pembrolizumab = Keytruda = Merck

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                      • G Offline
                        G Offline
                        GeorgeBest
                        wrote on sidst redigeret af
                        #139

                        Merck ejer pembro

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #140

                          Yes but that was because of an IMiD, wasn't it?

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #141

                            Recruitment Status : Withdrawn (Business Reasons) https://clinicaltrials.gov/ct2/show/NCT03221634

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #142

                              Lego: Atezo ejes af Roche. BMS ejer Opdivo - nivolumab

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #143

                                Nu vi snakker om BMS: "Den amerikanske medicinalkoncern Bristol-Myers Squibb, der for nyligt har gennemført det 74 mia. dollar store opkøb af biotekselskabet Celgene, har torsdag aflagt regnskab for fjerde kvartal, hvor indtjeningen overrasker positivt, mens prognoserne for 2020 er lidt til den svage side.
                                Aktien indikeres dog 3,0 pct. højere i det amerikanske formarked."

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #144

                                  article by your local Dara / MM hero...

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #145

                                    Controversy in the Use of CD38 Antibody for Treatment of Myeloma: Is High CD38 Expression Good or Bad? https://www.mdpi.com/2073-4409/9/2/378

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #146

                                      pdf
                                      https://sci-hub.tw/https://www.mdpi.com/2073-4409/9/2/378

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #147

                                        part of Special Issue "CD38 and Disease: A Bi-Directional Cross-Talk between Pathology and Physiology" https://www.mdpi.com/journal/cells/special_issues/CD38_CD157

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                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #148

                                          I don't quite get the point here. Do they recommend a dara-break or not?

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                                          0

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