Genmab — Oktober 2019

[GeorgeBest]

de 1-3 milliarder USD kan amyloidosis så passende kompensere for...

[E_L]

My understanding from the last JNJ R&D day was that they would wait with solid until the SC approval

[E_L]

Lebowitz said that in that earlier lung trial the concern was that steroids are taking away from the immune response. He adds: we have developped (and into the clinic) a steroid sparing regimen where we can get the streroids off -and we needed the SC to do that

[E_L]

And once we have those pieces in place I think we retest that hypothesis on immunomodulatory properties of darzalex

[E_L]

https://edge.media-server.com/mmc/p/jjsewqjm 4:33:30

[Sukkeralf]

Jan said earlier that they also needed approval of sc dara in MM first - they didnt want to jepardizy that with deaths in solids I guess

[E_L]

i remember you writing that exact sentence before

[Bulder]

Mht BMS-studierne i solide - dara-nivo - er der ikke meget tilbage. Der var vist 3. Det ene er lukket for rekruttering https://www.clinicaltrials.gov/ct2/show/NCT03098550?term=daratumumab+nivolumab&rank=2 Det andet er lukket i dara cohorten https://www.clinicaltrials.gov/ct2/show/NCT02488759?term=daratumumab+nivolumab&rank=4

[E_L]

So it has been 1 of the other reasons i thought SC approval is so important; it could mean the start of new trials imho...

[E_L]

then again, who knows now what HexaBody-CD38 will bring? We can assume that it is either more potent of safer -or both , if they go through with it, so maybe a more obvious partner for solid combinations...

[Bulder]

Tilbage er der kun checkmate 142, som også er lukket for rekruttering, men det kan være fordi de er ved at være færdige. https://www.clinicaltrials.gov/ct2/show/NCT02060188?term=daratumumab+nivolumab&rank=5

[Legolas23]

Spændende med BMS-studierne.

[E_L]

Jan criticizing recent Galapagos deal in the Dutch press , thinks they gave away too much
https://fd.nl/ondernemen/1318588/genmab-topman-galapagos-deal-had-ik-nooit-gedaan#

[peter12]

"Jeg ville aldrig gøre en sådan aftale, som Galapagos gjorde," siger Van de Winkel. "Jeg er kritisk."
Et af spørgsmålene er, at Galapagos har overdraget de amerikanske salgsrettigheder til sine lægemidler til Gilead. ”Det forstår jeg ikke,” siger Van de Winkel. ”De har opgivet det største marked. Jeg ville beholde mindst halvdelen af de amerikanske rettigheder. "

[peter12]

”Jeg betragter Onno som en ven,” siger Van de Winkel, men han frygter, at Van de Stolpe nu har gjort for mange indrømmelser. Han påpeger, at Gilead har fået ret til at købe alle vellykkede Galapagos-udviklingsprogrammer. "Dermed opgiver du al fremtidens opside."
Genmabs administrerende direktør forudser også, at opretholdelse af uafhængighed er relativ, da Gilead kan erhverve en næsten 30% andel i Galapagos. Gilead leverer også to tilsynsdirektører. "Galapagos er nu næsten en del af Gilead."

[gentogen]

Helt gratis er det trods alt ikke: Galapagos will receive a $3.95 billion upfront payment and a $1.1 billion equity investment from Gilead.

[Solsen]

Den dag JW laver en partneraftale med max 50% af US rettighederne til partner bliver stor

[nohope]

Den berømte 2 torsdage i en uge ?

[Solsen]

Det bliver jo nok først i 2020. Men mon ikke det kommer nu da JW har høj cigarføring også i udtalelserne ift Galapagos.

[peter12]

Lidt om Galapagos dealen https://www.evaluate.com/vantage/articles/news/deals/through-gilead-galapagos-secures-independent-future