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Genmab — Oktober 2019

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #419

    Lebowitz said that in that earlier lung trial the concern was that steroids are taking away from the immune response. He adds: we have developped (and into the clinic) a steroid sparing regimen where we can get the streroids off -and we needed the SC to do that

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #420

      And once we have those pieces in place I think we retest that hypothesis on immunomodulatory properties of darzalex

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #421

        https://edge.media-server.com/mmc/p/jjsewqjm 4:33:30

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        • S Offline
          S Offline
          Sukkeralf
          wrote on sidst redigeret af
          #422

          Jan said earlier that they also needed approval of sc dara in MM first - they didnt want to jepardizy that with deaths in solids I guess

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #423

            i remember you writing that exact sentence before 😉

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #424

              Mht BMS-studierne i solide - dara-nivo - er der ikke meget tilbage. Der var vist 3. Det ene er lukket for rekruttering https://www.clinicaltrials.gov/ct2/show/NCT03098550?term=daratumumab+nivolumab&rank=2 Det andet er lukket i dara cohorten https://www.clinicaltrials.gov/ct2/show/NCT02488759?term=daratumumab+nivolumab&rank=4

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #425

                So it has been 1 of the other reasons i thought SC approval is so important; it could mean the start of new trials imho...

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #426

                  then again, who knows now what HexaBody-CD38 will bring? We can assume that it is either more potent of safer -or both , if they go through with it, so maybe a more obvious partner for solid combinations...

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #427

                    Tilbage er der kun checkmate 142, som også er lukket for rekruttering, men det kan være fordi de er ved at være færdige. https://www.clinicaltrials.gov/ct2/show/NCT02060188?term=daratumumab+nivolumab&rank=5

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                    • Legolas23L Offline
                      Legolas23L Offline
                      Legolas23
                      wrote on sidst redigeret af
                      #428

                      Spændende med BMS-studierne.

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #429

                        Jan criticizing recent Galapagos deal in the Dutch press , thinks they gave away too much
                        https://fd.nl/ondernemen/1318588/genmab-topman-galapagos-deal-had-ik-nooit-gedaan#

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                        • P Offline
                          P Offline
                          peter12
                          wrote on sidst redigeret af
                          #430

                          "Jeg ville aldrig gøre en sådan aftale, som Galapagos gjorde," siger Van de Winkel. "Jeg er kritisk."
                          Et af spørgsmålene er, at Galapagos har overdraget de amerikanske salgsrettigheder til sine lægemidler til Gilead. ”Det forstår jeg ikke,” siger Van de Winkel. ”De har opgivet det største marked. Jeg ville beholde mindst halvdelen af de amerikanske rettigheder. "

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                          • P Offline
                            P Offline
                            peter12
                            wrote on sidst redigeret af
                            #431

                            ”Jeg betragter Onno som en ven,” siger Van de Winkel, men han frygter, at Van de Stolpe nu har gjort for mange indrømmelser. Han påpeger, at Gilead har fået ret til at købe alle vellykkede Galapagos-udviklingsprogrammer. "Dermed opgiver du al fremtidens opside."
                            Genmabs administrerende direktør forudser også, at opretholdelse af uafhængighed er relativ, da Gilead kan erhverve en næsten 30% andel i Galapagos. Gilead leverer også to tilsynsdirektører. "Galapagos er nu næsten en del af Gilead."

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                            • G Offline
                              G Offline
                              gentogen
                              wrote on sidst redigeret af
                              #432

                              Helt gratis er det trods alt ikke: Galapagos will receive a $3.95 billion upfront payment and a $1.1 billion equity investment from Gilead.

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                              • SolsenS Offline
                                SolsenS Offline
                                Solsen
                                wrote on sidst redigeret af
                                #433

                                Den dag JW laver en partneraftale med max 50% af US rettighederne til partner bliver stor 😉

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                                • nohopeN Offline
                                  nohopeN Offline
                                  nohope
                                  wrote on sidst redigeret af
                                  #434

                                  Den berømte 2 torsdage i en uge ?

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                                  • SolsenS Offline
                                    SolsenS Offline
                                    Solsen
                                    wrote on sidst redigeret af
                                    #435

                                    Det bliver jo nok først i 2020. Men mon ikke det kommer nu da JW har høj cigarføring også i udtalelserne ift Galapagos.

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                                    • P Offline
                                      P Offline
                                      peter12
                                      wrote on sidst redigeret af
                                      #436

                                      Lidt om Galapagos dealen https://www.evaluate.com/vantage/articles/news/deals/through-gilead-galapagos-secures-independent-future

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                                      • P Offline
                                        P Offline
                                        peter12
                                        wrote on sidst redigeret af
                                        #437

                                        Deres market cap er ikke langt fra Genmabs selv om de vist ikke har tjent nogen penge endnu ?

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                                        • P Offline
                                          P Offline
                                          peter12
                                          wrote on sidst redigeret af
                                          #438

                                          Ny dara fabrik i Irland ? https://www.echolive.ie/corknews/200-new-jobs-created-at-Cork-manufacturing-plant-112eb97a-35d3-4b79-85ef-74e03a4a8434-ds

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