Genmab — September 2019
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Selvfølgelig har Ocrelizumab en stor fordel i dosis med en knockouteffekt. Men hvad er den langvarige virkning mht dels effekt men ikke mindst sideeffects grundet et bedre og intakt immunforsvar samt at antistoffet er humant således, at overfølsomhed undgåes. Jeg var imponeret over det relativt lave antal pml tilfælde i Ocrelizumab til dato - det kunne have været en achilleshæl for Roche. Men niveauet er sikkert acceptabelt.
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https://en.m.wikipedia.org/wiki/Ocrelizumab Ved læsning af denne ses dog en del problemer grundet det pressede immunforsvar ved Ocrelizumab behandling.
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https://www.ocrelizumabinfo.global/content/dam/ocrelizumab/global/en/documents/P4_2_025_AAN_2019_SafetyUpdatePoster_Global_Hauser_et_al_Supplemental_Mats_V2.pdf Analyse af sideeffects ved ocrelizumab.
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Tak Solsen.
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God morgen.
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not sure if this new trial was posted already : Study to Evaluate the Efficacy and Safety of Camidanlumab Tesirine (ADCT-301) in Patients With Relapsed or Refractory Hodgkin Lymphoma https://clinicaltrials.gov/ct2/show/NCT04052997?term=Camidanlumab&rank=1
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yes, that made me revisit this. here is the SEC form F1 https://sec.report/Document/0001140361-19-016305/
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and then i also thought "Risks Related to Our Relationship with Third Parties" was interesting as it says "Our rights to ADCT-301 are subject to our collaboration and license agreement with Genmab, and there can be no assurance that we will maintain the rights to develop or commercialize ADCT-301."
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