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Genmab — August 2019

Planlagt Fastgjort Låst Flyttet Genmab
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  • BulderB Offline
    BulderB Offline
    Bulder
    wrote on sidst redigeret af
    #1646

    Thx GB. I was not sure about that. Where did you find that info?

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    • G Offline
      G Offline
      GeorgeBest
      wrote on sidst redigeret af
      #1647

      Bulder: can you read Nordea comments from 22 August?

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      • SolsenS Offline
        SolsenS Offline
        Solsen
        wrote on sidst redigeret af
        #1648

        In the announcement they mentioned 4 lines or less

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        • G Offline
          G Offline
          GeorgeBest
          wrote on sidst redigeret af
          #1649

          Nordea write: patients had failed 4 or more prior lines of therapy including platinum based chemo

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          • SolsenS Offline
            SolsenS Offline
            Solsen
            wrote on sidst redigeret af
            #1650

            Makes a difference - perhaps Iam wrong

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            • G Offline
              G Offline
              GeorgeBest
              wrote on sidst redigeret af
              #1651

              So infact EnaV is 5th line...

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              • SolsenS Offline
                SolsenS Offline
                Solsen
                wrote on sidst redigeret af
                #1652

                who had failed ≤4 prior lines of therapy - right

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                • SolsenS Offline
                  SolsenS Offline
                  Solsen
                  wrote on sidst redigeret af
                  #1653

                  https://wclc2019.iaslc.org/wp-content/uploads/2019/08/WCLC2019-Abstract-Book_web-friendly.pdf pp 217-218

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                  • SolsenS Offline
                    SolsenS Offline
                    Solsen
                    wrote on sidst redigeret af
                    #1654

                    Difficult comparison to Bergenbios compound.

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                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #1655

                      patients with stage III/IV
                      NSCLC without sensitizing EGFR mutations (EGFR WT) or ALK
                      rearrangements (ALK-
                      ) who had failed ≤4 prior lines of therapy, så nogle har haft færre end 4 behandlinger.

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #1656

                        Bergenbio: Cohort A will consist of patients who received a maximum of 1 prior line of platinum-containing chemotherapy and no prior immunotherapy of any kind. Cohort B will consist of patients with a maximum of 2 prior lines whereas the most recent line must have included a PD-(L)1 inhibitor.

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                        • nohopeN Offline
                          nohopeN Offline
                          nohope
                          wrote on sidst redigeret af
                          #1657

                          Er det egentlig ikke et lidt underligt kriterium ? Mindre end 4 - så kan det være 0-1-2-3-4 ? Det ville være mere logisk hvis det hed 4 eller flere ?

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #1658

                            Det betyder op til og med 4. linje.

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #1659

                              ... eller ned om man vil

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                              • nohopeN Offline
                                nohopeN Offline
                                nohope
                                wrote on sidst redigeret af
                                #1660

                                Det er jeg med på, men synes stadig det er underligt kriterium.

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                                • nohopeN Offline
                                  nohopeN Offline
                                  nohope
                                  wrote on sidst redigeret af
                                  #1661

                                  Når du eksperimenterer så plejer du at få dem der opgivet?

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                                  • S Offline
                                    S Offline
                                    Sukkeralf
                                    wrote on sidst redigeret af
                                    #1662

                                    Just a moment...

                                    favicon

                                    (www.firstwordpharma.com)

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                                    • S Offline
                                      S Offline
                                      Sukkeralf
                                      wrote on sidst redigeret af
                                      #1663

                                      Svært at sammenligne Genmabs ADC med BergenBios bemcentinib - et underligt dilemma er også, at patienter skal være godt syge for at udtrykke AXL. Tænker umiddelbart at Bemcentinib og EnaV vil sigte efter forskellige patientgrupper

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                                      • S Offline
                                        S Offline
                                        Sukkeralf
                                        wrote on sidst redigeret af
                                        #1664

                                        Man skal nok mere bekymre sig om Daiichi Sankyo´s TROP2 ADC - noget tyder på at de har knækket koden med ADC således, at de i hvert fald kan opnå god effekt. De mangler måske stadig et bedre terapeutisk vindue, så de også kan slippe af med bivirkningerne

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                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #1665

                                          Ud fra det GB citerer 9:54 er det i hvert fald ikke rigtigt, hvad Nordea skriver. Det er ikke 4 eller flere. Det er 4 eller færre.

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