Genmab — Februar 2019

[E_L]

That is why i would have liked to have seen a bit more feedback ; trying it in lung cancer, with dexamethason might have been a really stupid idea…

[Bulder]

According to Limo Chen's findings lung cancer seemed to be a good idea.

[E_L]

Limo will not have thought about the side effects of the dex. JNJ should have. But all speculation, the chapter is closed until further news.

[Sukkeralf]

Jan said once that if Janssen continued in solid tumours it will be with sc dosing and first after approval i MM - no need to jeopadize with unpleasent deaths in a solid tumour trial

[E_L]

ok, i had not heard that before. That actually makes sense if i am honest.

[Sukkeralf]

The last couples of times he just said that solid tumours are dead - and he will not take any more beating.........poor guy

[Solsen]

I think Jan did say that analyst should put solids to zero because he would avoid that they did write the indication off two times

[Solsen]

JNJ have trials with sc in solids.

[Bulder]

Agree with Solsen. A bit different than saying it's dead.

[Bulder]

In solids? They have in healthy people

[Bulder]

Interesting purpose by the way: to determine whether premedication with corticosteroids is required to improve the tolerability of SC administration of daratumumab in healthy participants.

[Sukkeralf]

Solsen agree with Jans words

[Sukkeralf]

sc in solids - do you have a link to that study?

[JørgenVarnæs]

Halozyme kører flere sc programmer på solide. Er det mon dem?

[Sukkeralf]

Ja men ikke med dara

[JørgenVarnæs]

det er også mine tanker. Jeg har ikke hørt om dara sc programmer

[Bulder]

Jeg troede også først lige at han underforstod sc dara. Men dette her er da delvist sc https://clinicaltrials.gov/ct2/show/NCT02908906?term=janssen+sc+solid&rank=1

[Solsen]

Der er et par små studier, hvor dara anvendes før og efter operation i bl.a. prostata - har ikke tid til at finde dem. Men det må være "solids"

[Bulder]

Ja, MD Anderson har i hvert fald et, men det er IV https://clinicaltrials.gov/ct2/show/NCT03177460?term=daratumumab+prostate&rank=2

[JørgenVarnæs]

jeg troede ikke, at volumen kunne blive ringere. Men jeg tog betydeligt fejl