Genmab — Januar 2019
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ER der nogen der kender Melflufen https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=9&cad=rja&uact=8&ved=2ahUKEwib2PWByfTfAhXJDywKHeDtDkYQFjAIegQIBBAC&url=https%3A%2F%2Fwww.oncopeptides.se%2Fen%2Fwp-content%2Fuploads%2Fsites%2F2%2F2019%2F01%2Foncopeptides-jpm-2019-3.pdf ? Kan se at der køre forsøg med dara ...
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https://www.ashclinicalnews.org/on-lo cation/good-news-horizon-melflufen-induces-response-heavily-refractory-myeloma/ https://netdoktor.dk/medicin/skema/cytostatika.htm
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Sukkeralf (eller andre der har faglig viden omkring dette:), fra ADC Therapeutics hjemmeside, som du så venligt linkede til i går (om ADCT-301 interim data på 113 HL patienter i ph Ia/Ib):
"In HL patients with a median of five prior lines of therapy and no other approved therapy options, the overall response rate was 86.5 percent, including a 43 percent compl
ete response rate,.." -
Som lægmand drister jeg mig til at spørge: Er dette ikke vildt imponerende tal i 6. linje.. det er vel ikke normalt at man kan få en så høj responsrate (specielt CR - kræft ikke målbar længere - på næsten halvdelen) hos patienter, der har prøvet så mange andre behandlinger
først? -
Og hvordan ville man have stillet sig, hvis tallene havde været 1. linje.. det ville være så fedt hvis du kunne sige lidt generelt (vedr. kræft bredt og/eller specifikt HL/MM) omkring sammenhængen mellem muligheden for "dyb" respons og hvilken linje man behandler?
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Her linket til ADC Therapeutics igen https://adctherapeutics.com/
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Have you got any thoughts on response rates on a late 6. line? (It was probably discussed here after ASH.) And any insights into correlation between possibility for "deep" response and how far down treament-regime one is? (maybe also that was discussed here after ASH..)
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Linker teknologien er rigtig vigtig. Linkeren kløves når ADCen transporteres ind i cellen og giften frigives. Der har været problemer med bivirkninger fordi linkeren kløves for tidligt...husker i hvert fald at immunogen havde problemer. SGEN har masser af validering af deres teknologi, så nok derfor Genmab kigger mod dem.
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