Genmab — November 2018
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Genmabs release, a bit easier to find the important ones https://ir.genmab.com/news-releases/news-release-details/genmab-announces-data-be-presented-2018-ash-annual-meeting
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Thirty-five total abstracts on Genmab owned and partnered programs scheduled for presentation at ASH
•Three abstracts related to Genmab owned programs: DuoBody
-CD3xCD20 & DuoHexaBody
-CD37
•Daratumumab: 5 oral presentations; total of 30 accepted including ISS -
To prove the anti-leukemic activity of daratumumab in AML in vivo https://ash.confex.com/ash/2018/webprogram/Paper113287.html
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Conclusions: CyBorD-DARA is a highly active, well tolerated induction therapy for NDMM patients undergoing ASCT. https://ash.confex.com/ash/2018/webprogram/Paper112375.html
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Conclusions:
CyBorD-DARA is a highly active, well tolerated induction therapy for NDMM patients undergoing ASCT. https://ash.confex.com/ash/2018/webprogram/Paper112375.html -
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Addition of tretinoin (ATRA) induced a ~4-fold increase of CD38 expression in AML blasts and to a lower extent in normal donor cells. In fact, combination of tretinoin and daratumumab led to an enhanced anti-leukemic activity in AML - Vi mangler i den grad in vivo data og burde vel have dem nu !
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