Genmab — Oktober 2018

[E_L]

response was 4.9 months and median PFS was 4.2 months by IIR.

[E_L]

Conclusions

These data demonstrate that TV has encouraging activity in previously treated recurrent or metastatic cervical cancer, an underserved population with a high unmet need, and that responses observed with TV are numerically higher than those achieved by historical controls. These data support the continued investigation of TV in this population.

Clinical trial identification

NCT02001623.

[E_L]

(End)

[Bulder]

Tak E L.
41% ORR heraf 1 CR - er det godt?

[Bulder]

Tyder på bedre responsrate end i rapporten fra sidste år (32%)

[Darvin]

Thanks E L - lidt forvirret. ORR er højere end sidst men median ser ud til at være kortere.

[JørgenVarnæs]

Kom N=34 resultaterne ikke fra dose eskaleringen_

[Bulder]

Hvad var responsvarigheden sidst?

[E_L]

So, standard of care beyond 1L treatment and 2L response rates of ∼13%

[E_L]

Last year n=34, investigator assessed ORR 32% (26% confirmed) median age 44

[E_L]

Now n=55, investigator assessed ORR 41% (24% confirmed) median age 47

[Bulder]

Do you happen to know the duration of response last year?

[Bulder]

Nevertheless, 41% is far better than 13%

[Bulder]

The 41% ORR was found by IIR (independent imaging review ) and not INV as far as I can see.

[E_L]

found last year https://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/A-Phase-IIa-Study-of-Tisotumab-Vedotin-HuMax-R-TF-ADC-in-Patients-With-Relapsed-Recurrent-and-or-Metastatic-Cervical-Cancer

[E_L]

10.34 you are correct

[bibob]

@Bulder. - whats the different. ?

[Bulder]

Tx. But it doesn't tell us duration og response. Darvin, What do you mean by "median" looks shorter?

[Bulder]

Bibob, I think IIR is more stringent, without possible bias.

[bibob]

Ok. Thanks.