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Genmab — September 2018

Planlagt Fastgjort Låst Flyttet Genmab
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  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #739

    De 10 næste er mlilestone pakken 191 millioner dollars pr program og royalty i samme stil

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    • G Offline
      G Offline
      gentogen
      wrote on sidst redigeret af
      #740

      Det Jan omtalte fra Journal of clinical oncology: "Conclusion:
      Baseline corticosteroid use of ≥ 10 mg of prednisone equivalent was associated with poorer outcome in patients with non–small-cell lung cancer who were treated with PD-(L)1 blockade. Prudent use of corticosteroids at the time of initiating PD-(L)1 blockade is recommended."

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      • G Offline
        G Offline
        gentogen
        wrote on sidst redigeret af
        #741

        corticosteroids were associated with decreased overall response rate, progression-free survival, and overall survival with PD-(L)1 blockade.

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        • G Offline
          G Offline
          gentogen
          wrote on sidst redigeret af
          #742

          Just a moment...

          favicon

          (ascopubs.org)

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #743

            Winkel var inde på at isatuximab-folkene måske havde knækket koden i solide. I hvert fald fastholder de kombi-forsøget med Cemiplimab (PD-1 blokker) i prostata cancer og nsclc https://www.clinicaltrials.gov/ct2/show/NCT03367819?term=isatuximab+nsclc&rank=1

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #744

              Cemiplimab https://investor.regeneron.com/news-releases/news-release-details/regeneron-and-sanofi-share-first-positive-clinical-data/

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #745

                Her er det nye studie, som Winkel omtaler, med isa i diverse solide https://www.clinicaltrials.gov/ct2/show/NCT03637764?term=isatuximab&draw=2&rank=11

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #746

                  I hvert fald ser han en fremtid for dara med den subkutane formulering i solide.

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                  • G Offline
                    G Offline
                    GeorgeBest
                    wrote on sidst redigeret af
                    #747

                    @Bulder/Sukkeralf/Solsen - I går udtalte Jan at DR5 var 100 gange mere potent end en nøgen antibody. Er dara eller ofa en nøgen antibody? Vil det sige at der er mulighed for at DR5 kan udvikle sig til et meget kraftigere medicament
                    end f.eks. dara?

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                    • P Offline
                      P Offline
                      pcf
                      wrote on sidst redigeret af
                      #748

                      http://files.shareholder.com/downloads/JNJ/6383638256x0x983792/7CF8F179-2C61-4A19-A94A-4A630E435993/Pharm_Analyst_Webcast_Slides_FINAL_9-12-18.

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                      • T Offline
                        T Offline
                        transalp
                        wrote on sidst redigeret af
                        #749

                        Tak pcf..

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                        • SolsenS Offline
                          SolsenS Offline
                          Solsen
                          wrote on sidst redigeret af
                          #750

                          Dara og Ofa er nøgne antistoffer. Ved at stofferne er mere potente opnås bedre sandsynlighed for bedre effekt før toxitet begrænser brugen - lidt generaliseret.

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                          • SolsenS Offline
                            SolsenS Offline
                            Solsen
                            wrote on sidst redigeret af
                            #751

                            Vel også bedre sandsynlighed for sc brug.

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                            • SolsenS Offline
                              SolsenS Offline
                              Solsen
                              wrote on sidst redigeret af
                              #752

                              DR5 bliver ikke konkurrent til hverken dara eller ofa.

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                              • G Offline
                                G Offline
                                GeorgeBest
                                wrote on sidst redigeret af
                                #753

                                DR5 er vel rettet mod solide. Så DR5 kan have stærkere virkning end nøgen antistof, men også en større risiko for bivirkninger. Rigitg forstået?

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                                • SolsenS Offline
                                  SolsenS Offline
                                  Solsen
                                  wrote on sidst redigeret af
                                  #754

                                  Større sandsynlighed for at opnå den ønskede effekt og bedre sandsynlighed for at optimal dosis ligger indenfor en acceptabel bivirkningsprofil.

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                                  • G Offline
                                    G Offline
                                    GeorgeBest
                                    wrote on sidst redigeret af
                                    #755

                                    Tak Solsen

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                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #756

                                      Hvis sc (indsprøjtning) er mulig vil det også være en stor fordel set med patientøjne samt konkurrencemæssigt en fordel pga kort kontakt med læger m.fl.

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #757

                                        MAIA data early 2019... is that what he just said?

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                                        • G Offline
                                          G Offline
                                          GeorgeBest
                                          wrote on sidst redigeret af
                                          #758

                                          I heard soon...and then he mentioned something with fireworks in 2019...

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