Genmab — September 2018

Bulder

kan hurtigt blive aktuelt

Sukkeralf

Just a moment...

(www.firstwordpharma.com)

E_L

early bird Sukkeralf…

E_L

this Dara SC trial re-opened for recruiting an extra 30 patients https://clinicaltrials.gov/ct2/history/NCT02519452?A=30&B=31&C=merged

E_L

If I am correct they are trying to see if they can do without corticosteroids??

Solsen

Isnt it the old PAVO study opened again. I would guess its the "Dara-CF" thats could be a new formulation. A good question to JW in a Q&A on PI.

Bulder

It's the original PAVO study. And yes it looks like they've made a part 3 - non-dex - with 30 pts.

Bulder

And it seems to be 2 sites in Spain that have reopened recruitment.

Solsen

You are both are right its described in "Study Description"

Solsen

They are optimistic about the sideeffect by trying without dex.

Bulder

And it's going to be very popular among pts and their relatives.

Solsen

The dara-cf sc is very important like MAIA is to the potential of dara. I would say crucial !

E_L

yes. and i am wondering if we can do without corticosteroids, if that would give a change on the effect with PD(L)1 on solids

Bulder

Winkel said that it was necessary to give dex to these very ill nsclc pts.

E_L

University Hospital of
Salamanca i think is where that Dr. Mateos works, from the Alcyone studie (feel like a real nerd now…)

E_L

ok

Bulder

She is one of the absolute top KOLs in MM.

Bulder

@ Sukkeralf: Hvad mener du om Alligators 4-1BB sammenlignet med Gens to nye duobodies. Umiddelbart virker de mere avancerede og sikre med deres dæmpede Fc-region?

Helge_LarsenPI-redaktør

Jeg er i spæd dialog med Alligator om et eventuelt samarbejde med Proinvestor incl. analyse på selskabet. https://alligatorbioscience.se/en/about-alligator/

AH2005

@Bulder: hvad står KOL for i den sætning? "She is one of the absolute top KOLs in MM."