Genmab — September 2018

[E_L]

this Dara SC trial re-opened for recruiting an extra 30 patients https://clinicaltrials.gov/ct2/history/NCT02519452?A=30&B=31&C=merged

[E_L]

If I am correct they are trying to see if they can do without corticosteroids??

[Solsen]

Isnt it the old PAVO study opened again. I would guess its the "Dara-CF" thats could be a new formulation. A good question to JW in a Q&A on PI.

[Bulder]

It's the original PAVO study. And yes it looks like they've made a part 3 - non-dex - with 30 pts.

[Bulder]

And it seems to be 2 sites in Spain that have reopened recruitment.

[Solsen]

You are both are right its described in "Study Description"

[Solsen]

They are optimistic about the sideeffect by trying without dex.

[Bulder]

And it's going to be very popular among pts and their relatives.

[Solsen]

The dara-cf sc is very important like MAIA is to the potential of dara. I would say crucial !

[E_L]

yes. and i am wondering if we can do without corticosteroids, if that would give a change on the effect with PD(L)1 on solids

[Bulder]

Winkel said that it was necessary to give dex to these very ill nsclc pts.

[E_L]

University Hospital of
Salamanca i think is where that Dr. Mateos works, from the Alcyone studie (feel like a real nerd now…)

[E_L]

ok

[Bulder]

She is one of the absolute top KOLs in MM.

[Bulder]

@ Sukkeralf: Hvad mener du om Alligators 4-1BB sammenlignet med Gens to nye duobodies. Umiddelbart virker de mere avancerede og sikre med deres dæmpede Fc-region?

[Helge_LarsenPI-redaktør]

Jeg er i spæd dialog med Alligator om et eventuelt samarbejde med Proinvestor incl. analyse på selskabet. https://alligatorbioscience.se/en/about-alligator/

[AH2005]

@Bulder: hvad står KOL for i den sætning? "She is one of the absolute top KOLs in MM."

[Bulder]

Key Opinion Leader

[Helge_LarsenPI-redaktør]

Alligator: Nya prekliniska data stödjer goda säkerhetsegenskaper för 4-1BB-antikroppen ATOR-1017: https://alligatorbioscience.se/nya-prekliniska-data-stodjer-goda-sakerhetsegenskaper-for-4-1bb-antikroppen-ator-1017/

[Helge_LarsenPI-redaktør]

Genmab kan bære en høj P/E pga. vækstudsigter: http://www.proinvestor.com/investornyt/561383/genmab-kan-baere-en-hoj-p-e-pga-vaekstudsigter