Genmab — April 2018

[E_L]

oow, i dont know mcjean, you may have to split that order and divide it up over several banks

[E_L]

this Tisotumab Vedotin study - https://clinicaltrials.gov/ct2/history/NCT02001623?A=14&B=15&C=merged

• ; Status set to : Active, not recruiting , so i guess they are fully recruited , Enrollment: 170 instead of the 144 planned

[E_L]

Durable treatment response of relapsing CNS plasmacytoma using intrathecal chemotherapy, radiotherapy, and Daratumumab - https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.1451

[E_L]

"The role of Daratumumab in this disease deserves further evaluation. " click on PDF for full text

[E_L]

Teaching Drugs New Tricks - https://www.project-syndicate.org/commentary/pharmaceutical-industry-repositioning-old-drugs-by-aris-persidis-and-andreas-persidis-2018-04 - mentioning the Arzerra story

[Bulder]

Interesting E L: Currently, there are no available data to suggest Daratumumab could cross the BBB; however, the fact that, the barrier can become more permeable in disease states and that there is no barrier in the meninges raises this possibility.

[E_L]

yes, and also interesting that she is currently on week 68 of treatment in a disease with a median overall survival of < 6 months

[Bulder]

with a median overall survival of only 4.6 months - to be precise. Quite promising if it turns out that dara has the ability to penetrate the BBB. Also in other cancers maybe.

[JStudsgaard]

Fantastisk historie! Men hun har så vidt jeg kan læse været udsat for hjernekirurgi og fået dexamethasone, så hjernebarrieren kan være brudt/åben pga. det.

[JStudsgaard]

Var det i øvrigt ikke i dag der skulle komme Q1 salgstal fra Janssen?

[Bulder]

på tirsdag

[JStudsgaard]

OK tak

[bibob]

OHW 08.24. Du havde ret, vi kom under 1200. ;-). Håber du fik købt lidt inden stigningen kom.

[JKY_VH]

[Plimsoller]

God morgen

[Helge_LarsenPI-redaktør]

God morgen.

[polle1]

God morgen

[transalp]

go Morgen

[henrik48]

God morgen

[Parasitism]

God morgen