Genmab — April 2018

Mcjean

Yep if the let me i buy all 200 at once, do you think its possible?:-D

E_L

oow, i dont know mcjean, you may have to split that order and divide it up over several banks

E_L

this Tisotumab Vedotin study - https://clinicaltrials.gov/ct2/history/NCT02001623?A=14&B=15&C=merged

; Status set to : Active, not recruiting , so i guess they are fully recruited , Enrollment: 170 instead of the 144 planned

E_L

Durable treatment response of relapsing CNS plasmacytoma using intrathecal chemotherapy, radiotherapy, and Daratumumab - https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.1451

E_L

"The role of Daratumumab in this disease deserves further evaluation. " click on PDF for full text

E_L

Teaching Drugs New Tricks - https://www.project-syndicate.org/commentary/pharmaceutical-industry-repositioning-old-drugs-by-aris-persidis-and-andreas-persidis-2018-04 - mentioning the Arzerra story

Bulder

Interesting E L: Currently, there are no available data to suggest Daratumumab could cross the BBB; however, the fact that, the barrier can become more permeable in disease states and that there is no barrier in the meninges raises this possibility.

E_L

yes, and also interesting that she is currently on week 68 of treatment in a disease with a median overall survival of < 6 months

Bulder

with a median overall survival of only 4.6 months - to be precise. Quite promising if it turns out that dara has the ability to penetrate the BBB. Also in other cancers maybe.

JStudsgaard

Fantastisk historie! Men hun har så vidt jeg kan læse været udsat for hjernekirurgi og fået dexamethasone, så hjernebarrieren kan være brudt/åben pga. det.

JStudsgaard

Var det i øvrigt ikke i dag der skulle komme Q1 salgstal fra Janssen?

Bulder

på tirsdag

JStudsgaard

OK tak

bibob

OHW 08.24. Du havde ret, vi kom under 1200. ;-). Håber du fik købt lidt inden stigningen kom.

JKY_VH

Plimsoller

God morgen

Helge_LarsenPI-redaktør

God morgen.

polle1

God morgen

transalp

go Morgen

henrik48

God morgen