Genmab — Januar 2018
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"We've known about NAD+ for almost 100 years, so, for me, the best part was when we realized that this intrinsic factor was responsible for the cells' strength," says Mehrotra. "That we could pick out one molecule, CD38, and produce this robust anti-tumor phenotype just by knocking it down was a big surprise. I actually thought that it wouldn't work-that we wouldn't get robust tumor control with the CD38 knockout cells. But it turns out that its ability to regulate the important cofactor NAD+ is
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I hvert fald vil der være et problem med ventetiden. Ved ACT udtager man T-celler og kultiverer dem i uger eller mdr. Og i mellemtiden dør så patienten. Skeptikere ved car-t har netop peget på dette problem ved t-celle transplantationer i det hele taget.
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