Genmab — Januar 2018

[Solsen]

Th1/17 hybrid T cells offer potent and durable anti-tumor response in preclinical model

Adoptive cell therapy for cancer involves harvesting T cells from a patient and expanding and sometimes modifying them in the laboratory before reinfusion. It has been challenging to create T cells that are both potent and durable. In a new study, researchers report the potent anti-tumor properties of hybrid Th1/Th17 cells that combine the cancer-fighting properties of Th1 cells and the ability of Th17 cells to self-renew and regenerate.

ScienceDaily (www.sciencedaily.com)

[Mumtaz]

JKY jeg har ikke taget turen ned fra 1400 iden - kun i vestas - min snit i genmab er lavere end dagens kurs modsat vestas hvor klarsyn er sløret ;--)

[JKY_VH]

ja, verden er jo ikke perfekt:-)

[Solsen]

"We've known about NAD+ for almost 100 years, so, for me, the best part was when we realized that this intrinsic factor was responsible for the cells' strength," says Mehrotra. "That we could pick out one molecule, CD38, and produce this robust anti-tumor phenotype just by knocking it down was a big surprise. I actually thought that it wouldn't work-that we wouldn't get robust tumor control with the CD38 knockout cells. But it turns out that its ability to regulate the important cofactor NAD+ is

[Bulder]

Hvad får du ud af det Solsen? Det lyder som noget car-t-agtigt, hvor man udtager t-celler fra pt og laver en hybrid, som virker bedre, hvis cd38 bliver blokeret.

[Solsen]

But it turns out that its ability to regulate the important cofactor NAD+ is so vital, that just by inhibiting it we could make the T cells work better."

[Solsen]

Jeg håbede at du kunne vurdere det

[Solsen]

Men det viser ihvert tilfælde at dara kan være "magic bullet"

[Bulder]

ja, eller et andet cd38 antistof

[Solsen]

Jo. Men nu vil dara jo være kendt og derfor have en god mulighed, hvis der er noget i dette.

[Bulder]

I hvert fald vil der være et problem med ventetiden. Ved ACT udtager man T-celler og kultiverer dem i uger eller mdr. Og i mellemtiden dør så patienten. Skeptikere ved car-t har netop peget på dette problem ved t-celle transplantationer i det hele taget.

[Solsen]

Pointen er jo at cd38 spiller en central rolle for T-cellerne. Det hvad enten det er ACT eller "in natura"

[Solsen]

Endnu et bevis på at dara kan noget udenfor mm.

[Bulder]

Dara kan noget overalt - bare der er cd38 til stede. Og hvis der ikke er, så har vi SY-1425, der kan skaffe det.

[pauly]

nogen samler i alt fald aktierne op så de har set en god mulighed

[pauly]

Det tænker jeg ikke det er, men alt er vel muligt i dette spil. Det lyder heller ikke som en lovlig tilgang, men det er nok uden betydning. Reglerne gælder jo kun for private

[bongobob]

God morgen. En hurtig google viser der er en forbindelse " AHL Partners LLP lifted its stake in Artisan Partners Asset Management by 102.3% during the second quarter. AHL Partners LLP now owns 226,766 shares of the asset manager’s stock worth $6,962,000 after purchasing an additional 114,696 shares during the last quarter"

[bongobob]

Lad spekulationerne begynde

[pauly]

godt set af pensionisten

[Helge_LarsenPI-redaktør]

God morgen.