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Genmab — Januar 2018

Planlagt Fastgjort Låst Flyttet Genmab
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  • SolsenS Offline
    SolsenS Offline
    Solsen
    wrote on sidst redigeret af
    #710

    "We've known about NAD+ for almost 100 years, so, for me, the best part was when we realized that this intrinsic factor was responsible for the cells' strength," says Mehrotra. "That we could pick out one molecule, CD38, and produce this robust anti-tumor phenotype just by knocking it down was a big surprise. I actually thought that it wouldn't work-that we wouldn't get robust tumor control with the CD38 knockout cells. But it turns out that its ability to regulate the important cofactor NAD+ is

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    • BulderB Offline
      BulderB Offline
      Bulder
      wrote on sidst redigeret af
      #711

      Hvad får du ud af det Solsen? Det lyder som noget car-t-agtigt, hvor man udtager t-celler fra pt og laver en hybrid, som virker bedre, hvis cd38 bliver blokeret.

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      • SolsenS Offline
        SolsenS Offline
        Solsen
        wrote on sidst redigeret af
        #712

        But it turns out that its ability to regulate the important cofactor NAD+ is so vital, that just by inhibiting it we could make the T cells work better."

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        • SolsenS Offline
          SolsenS Offline
          Solsen
          wrote on sidst redigeret af
          #713

          Jeg håbede at du kunne vurdere det 🙂

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          • SolsenS Offline
            SolsenS Offline
            Solsen
            wrote on sidst redigeret af
            #714

            Men det viser ihvert tilfælde at dara kan være "magic bullet"

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #715

              ja, eller et andet cd38 antistof

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              • SolsenS Offline
                SolsenS Offline
                Solsen
                wrote on sidst redigeret af
                #716

                Jo. Men nu vil dara jo være kendt og derfor have en god mulighed, hvis der er noget i dette.

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #717

                  I hvert fald vil der være et problem med ventetiden. Ved ACT udtager man T-celler og kultiverer dem i uger eller mdr. Og i mellemtiden dør så patienten. Skeptikere ved car-t har netop peget på dette problem ved t-celle transplantationer i det hele taget.

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                  • SolsenS Offline
                    SolsenS Offline
                    Solsen
                    wrote on sidst redigeret af
                    #718

                    Pointen er jo at cd38 spiller en central rolle for T-cellerne. Det hvad enten det er ACT eller "in natura"

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                    • SolsenS Offline
                      SolsenS Offline
                      Solsen
                      wrote on sidst redigeret af
                      #719

                      Endnu et bevis på at dara kan noget udenfor mm.

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #720

                        Dara kan noget overalt - bare der er cd38 til stede. Og hvis der ikke er, så har vi SY-1425, der kan skaffe det. 😉

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                        • P Offline
                          P Offline
                          pauly
                          wrote on sidst redigeret af
                          #721

                          nogen samler i alt fald aktierne op så de har set en god mulighed

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                          • P Offline
                            P Offline
                            pauly
                            wrote on sidst redigeret af
                            #722

                            Det tænker jeg ikke det er, men alt er vel muligt i dette spil. Det lyder heller ikke som en lovlig tilgang, men det er nok uden betydning. Reglerne gælder jo kun for private 😄

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                            • bongobobB Offline
                              bongobobB Offline
                              bongobob
                              wrote on sidst redigeret af
                              #723

                              God morgen. En hurtig google viser der er en forbindelse " AHL Partners LLP lifted its stake in Artisan Partners Asset Management by 102.3% during the second quarter. AHL Partners LLP now owns 226,766 shares of the asset manager’s stock worth $6,962,000 after purchasing an additional 114,696 shares during the last quarter"

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                              0
                              • bongobobB Offline
                                bongobobB Offline
                                bongobob
                                wrote on sidst redigeret af
                                #724

                                Lad spekulationerne begynde

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                                • P Offline
                                  P Offline
                                  pauly
                                  wrote on sidst redigeret af
                                  #725

                                  godt set af pensionisten

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                                  0
                                  • Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktør
                                    wrote on sidst redigeret af
                                    #726

                                    God morgen. 🙂

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                                    0
                                    • BudweisB Offline
                                      BudweisB Offline
                                      Budweis
                                      wrote on sidst redigeret af
                                      #727

                                      God morgen.

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                                      • BudweisB Offline
                                        BudweisB Offline
                                        Budweis
                                        wrote on sidst redigeret af
                                        #728

                                        og interessant vinkel

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                                        0
                                        • J Offline
                                          J Offline
                                          JKY_VH
                                          wrote on sidst redigeret af
                                          #729

                                          God morgen og godt set pensionisten.

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                                          0

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