Genmab — Januar 2018

GeorgeBest

Indtægter fra 4-5 linie behandlinger kan ikke refærdiggøre det. Det same med Gilead der købte Kite for 12 mia USD...

nohope

De må se mere I det end 4-5 linie.

Sukkeralf

Det kunne være man skulle prøve at læse lidt om, hvad CAR-T selskaber selv mener det kan bruges til - og analytikere der følgeer disse selskaber

mobbyduck1

JUNO er oppe med 53% i premarket og Bluebird oppe med 8%

E_L

a bit more on NICE from MyelomaUK https://www.myeloma.org.uk/news/daratumumab-approved-for-use-on-the-nhs-in-england-and-wales/

Sukkeralf

Indeed, Celgene made it a point at ASH to emphasise the speed at which the company and bluebird will be moving bb2121 forward. A pivotal trial (KarMMa) in late-stage patients will treat an initial patient this month, and the partners plan to start a Phase III trial next year in the third-line setting while simultaneously evaluating the product even further upstream, with a goal of moving into newly diagnosed patients

E_L

should still bring a minumum of €35mn in revenue
in the UK this year, no?

Bulder

mærkeligt at det er kun 4. linje og ikke 4. linje eller senere.

E_L

yes... but it is correct according to p10 here https://www.england.nhs.uk/wp-content/uploads/2018/01/national-cdf-list-v1.59.pdf

Mcjean

Maybe more than 35mn E L. If the first have open for treatment, maybe some patient can apply but i really dont know but im sure the analytics have to rise the estimate, maybe to 2.3 - 2.7?

Mcjean

which will happen after 4q and that should result in higher rate, around 2000 i think:-)

Bulder

Lyder som chikane: "Note: The use of daratumumab will be audited to confirm it is being used in
accordance with these treatment criteria (particularly in respect of lines of therapy)
and non-compliant use will be monitored and followed-up."

E_L

funny how that works, whatever calculation you use , we end up at 2000

laerlingen

super dårlig til TA, men kan man betegne udviklingen i GEN som "cup a
nd handle"?

Mcjean

Yep the calulator always end up at 2000, but only this year, next year its gonna be wild:-)

E_L

MDs possibly have an easier choice now Bulder; after 3 lines they HAVE to choose Dara, otherwise the option is gone. If it doesn't work they can still try something else

E_L

@ laerlingen , I would personally think the handle is a bit small compared to the cup, but it is very subjective...

rex_pacis

@laerlingen jeg mener det ikke, den er for kort og ujævn

laerlingen

øv øv..men tak

E_L

I don't know TrinityDelta, but his is their research on BergenBio for those interested http://www.trinitydelta.org/bergenbio . At some point they do state: "while the most advanced antibody-based product in clinical development is
Genmab’s ADC, Humax-AXL-ADC."