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Genmab — September 2017

Planlagt Fastgjort Låst Flyttet Genmab
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  • J Offline
    J Offline
    Jedi
    wrote on sidst redigeret af
    #214

    More on UCART from Celletics http://www.cellectis.com/en/products/ucarts/ apparently, the next generation CAR-T is not quite ready yet...

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    0
    • J Offline
      J Offline
      Jedi
      wrote on sidst redigeret af
      #215

      The Cellectis UCART123 target CD123, different from the fatalities of CAR-T targeting CD19, but same sad result

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      0
      • S Offline
        S Offline
        Sukkeralf
        wrote on sidst redigeret af
        #216

        But we also saw Janssen/Genmab having problems with CD123/CD3 - probably not easy to engage the T-cell and av
        oid adverse effects

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        0
        • S Offline
          S Offline
          Sukkeralf
          wrote on sidst redigeret af
          #217

          But offcause with the bispecific CD3 antibodies you can stop giving the drug - thats the problem with CAR-T

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          0
          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #218

            Det er vel ikke target cd19/cd123, der er årsagen til cytokin-stormen?

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            0
            • S Offline
              S Offline
              Sukkeralf
              wrote on sidst redigeret af
              #219

              Link Preview Image
              Cytokine release syndrome - Wikipedia

              favicon

              (en.wikipedia.org)

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #220

                tak. Som jeg forstår det er cytokin-stormen en (uheldig) egenskab ved t-cellen og uafhængig af hvilket target den binder sig til?

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                • B Offline
                  B Offline
                  bibob
                  wrote on sidst redigeret af
                  #221

                  T-celle terapi er langt fra i mål. Patienter med samme diagnoser responderer jo forskelligt på samme behandling. Det ER et svært område at navigere i.

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                  • S Offline
                    S Offline
                    Sukkeralf
                    wrote on sidst redigeret af
                    #222

                    Bulder - enig. Bibob det gør patienter jo også ved alle mulige andre behandlinger.

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #223

                      good comment at 09.29... Blindingly obvious & very important problem for car-t, but I hadn't even thought of it that way
                      ...

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                      0
                      • B Offline
                        B Offline
                        bibob
                        wrote on sidst redigeret af
                        #224

                        Ja Sukker. - men Car-T kan du jo som du selv skrev ikke stoppe behandlingen. Og det er jo en ret væsentlig forskel.

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                        0
                        • B Offline
                          B Offline
                          bibob
                          wrote on sidst redigeret af
                          #225

                          Helge : Har lige brugt lidt feriepenge på en donation via mobilepay. Fik desværre ikke skrevet afs. 🙂

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                          • S Offline
                            S Offline
                            sowise
                            wrote on sidst redigeret af
                            #226

                            Pengemedper - https://blog.nordnet.dk/genmab-potentialet-udtoemt-aktie-40-dobling/04/09/2017/?autoplay=1

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                            • J Offline
                              J Offline
                              JohnW
                              wrote on sidst redigeret af
                              #227

                              DAX og C20CAP er vist ikke helt enige om retningen i dag.

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                              0
                              • J Offline
                                J Offline
                                jkj
                                wrote on sidst redigeret af
                                #228

                                Godt nok en ultra tynd handel i dag.

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                                0
                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #229

                                  page 19 shows Cellectis had Rituximab as suicide switch imbedded in the CAR molecul
                                  e http://www.cellectis.com/uploads/files/20170901_Cellectis_CLLS.pdf

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                                  0
                                  • Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktør
                                    wrote on sidst redigeret af
                                    #230

                                    Tusinde tak bibob. 🙂

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                                    0
                                    • P Offline
                                      P Offline
                                      polle1
                                      wrote on sidst redigeret af
                                      #231

                                      Har I nogen forventning om nyheder/overraskelser på ESMO, som kunne være positivt kurspåvirkende ?

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                                      0
                                      • J Offline
                                        J Offline
                                        jkj
                                        wrote on sidst redigeret af
                                        #232

                                        Forventningerne virker ikke store i marked, så hvis der kommer bemærkesværdige data, så ville det kunne være en mindre
                                        .

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                                        0
                                        • J Offline
                                          J Offline
                                          jkj
                                          wrote on sidst redigeret af
                                          #233

                                          tricker

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                                          0

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