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Genmab — September 2017

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • J Offline
    J Offline
    JKY_VH
    wrote on sidst redigeret af
    #209

    God morgen og tak bibob

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #210

      aren't these the same links as we discussed on Thursday morning?

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      • B Offline
        B Offline
        bibob
        wrote on sidst redigeret af
        #211

        I really dont know. Just seeing them

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #212

          no worries bibob, better too often as not at all;
          enjoy you coffee in the sun 😉

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #213

            Cellectis Reports Clinical Hold of UCART123 Studies http://www.businesswire.com/news/home/20170904005410/en/

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            • J Offline
              J Offline
              Jedi
              wrote on sidst redigeret af
              #214

              More on UCART from Celletics http://www.cellectis.com/en/products/ucarts/ apparently, the next generation CAR-T is not quite ready yet...

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              • J Offline
                J Offline
                Jedi
                wrote on sidst redigeret af
                #215

                The Cellectis UCART123 target CD123, different from the fatalities of CAR-T targeting CD19, but same sad result

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                • S Offline
                  S Offline
                  Sukkeralf
                  wrote on sidst redigeret af
                  #216

                  But we also saw Janssen/Genmab having problems with CD123/CD3 - probably not easy to engage the T-cell and av
                  oid adverse effects

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                  • S Offline
                    S Offline
                    Sukkeralf
                    wrote on sidst redigeret af
                    #217

                    But offcause with the bispecific CD3 antibodies you can stop giving the drug - thats the problem with CAR-T

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                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #218

                      Det er vel ikke target cd19/cd123, der er årsagen til cytokin-stormen?

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                      • S Offline
                        S Offline
                        Sukkeralf
                        wrote on sidst redigeret af
                        #219

                        Link Preview Image
                        Cytokine release syndrome - Wikipedia

                        favicon

                        (en.wikipedia.org)

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #220

                          tak. Som jeg forstår det er cytokin-stormen en (uheldig) egenskab ved t-cellen og uafhængig af hvilket target den binder sig til?

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                          • B Offline
                            B Offline
                            bibob
                            wrote on sidst redigeret af
                            #221

                            T-celle terapi er langt fra i mål. Patienter med samme diagnoser responderer jo forskelligt på samme behandling. Det ER et svært område at navigere i.

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                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #222

                              Bulder - enig. Bibob det gør patienter jo også ved alle mulige andre behandlinger.

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #223

                                good comment at 09.29... Blindingly obvious & very important problem for car-t, but I hadn't even thought of it that way
                                ...

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                                • B Offline
                                  B Offline
                                  bibob
                                  wrote on sidst redigeret af
                                  #224

                                  Ja Sukker. - men Car-T kan du jo som du selv skrev ikke stoppe behandlingen. Og det er jo en ret væsentlig forskel.

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                                  • B Offline
                                    B Offline
                                    bibob
                                    wrote on sidst redigeret af
                                    #225

                                    Helge : Har lige brugt lidt feriepenge på en donation via mobilepay. Fik desværre ikke skrevet afs. 🙂

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                                    • S Offline
                                      S Offline
                                      sowise
                                      wrote on sidst redigeret af
                                      #226

                                      Pengemedper - https://blog.nordnet.dk/genmab-potentialet-udtoemt-aktie-40-dobling/04/09/2017/?autoplay=1

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                                      • J Offline
                                        J Offline
                                        JohnW
                                        wrote on sidst redigeret af
                                        #227

                                        DAX og C20CAP er vist ikke helt enige om retningen i dag.

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                                        • J Offline
                                          J Offline
                                          jkj
                                          wrote on sidst redigeret af
                                          #228

                                          Godt nok en ultra tynd handel i dag.

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