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Genmab — Januar 2017

Planlagt Fastgjort Låst Flyttet Genmab
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  • Helge_LarsenPI-redaktørH Offline
    Helge_LarsenPI-redaktørH Offline
    Helge_LarsenPI-redaktør
    wrote on sidst redigeret af
    #859

    Enig Bulder.

    1 Reply Last reply
    0
    • J Offline
      J Offline
      JPW
      wrote on sidst redigeret af
      #860

      Hvad er forventningerne til salgstal den 18 januar?

      1 Reply Last reply
      0
      • M Offline
        M Offline
        mobbyduck1
        wrote on sidst redigeret af
        #861

        60-70 mio herfra, andre der er meget højere, men det er nok ret realistisk

        1 Reply Last reply
        0
        • B Offline
          B Offline
          bibob
          wrote on sidst redigeret af
          #862

          Tror du rammer intervallet meget godt mobbyduck. Alt derover vil være fremragende:-)

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          0
          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #863

            Fik først nu øje på jkj's link til FW-pharma. De kommercielle forventninger til Darzalex er øget substantielt ud over de 9 mia peaksale i MM. Det bliver sværere og sværere at bevare pessimismen.

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            • B Offline
              B Offline
              bibob
              wrote on sidst redigeret af
              #864

              Celgene strikes possible takeover deal for in- demand Anokion

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              • B Offline
                B Offline
                bibob
                wrote on sidst redigeret af
                #865

                Immatics bags $ 1 B tie- up With Amgen for cancer immune therapies

                1 Reply Last reply
                0
                • B Offline
                  B Offline
                  bibob
                  wrote on sidst redigeret af
                  #866

                  Begge nyheder idag på Fierce Biotek. ( kan desværre ikke linke )

                  1 Reply Last reply
                  0
                  • G Offline
                    G Offline
                    GeorgeBest
                    wrote on sidst redigeret af
                    #867

                    Access denied | www.fiercebiotech.com used Cloudflare to restrict access | www.fiercebiotech.com | Cloudflare

                    favicon

                    (www.fiercebiotech.com)

                    1 Reply Last reply
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                    • G Offline
                      G Offline
                      GeorgeBest
                      wrote on sidst redigeret af
                      #868

                      Access denied | www.fiercebiotech.com used Cloudflare to restrict access | www.fiercebiotech.com | Cloudflare

                      favicon

                      (www.fiercebiotech.com)

                      1 Reply Last reply
                      0
                      • G Offline
                        G Offline
                        gentogen
                        wrote on sidst redigeret af
                        #869

                        the HDACi Panobinostat induces upregulation of CD38 on myeloma and a subsequent dramatic increase of Daratumumab-mediated ADCC in pre-clinical models. Fra Blood 2016 128:4481. Panobinostat er Novartis (Farydak)

                        1 Reply Last reply
                        0
                        • G Offline
                          G Offline
                          gentogen
                          wrote on sidst redigeret af
                          #870

                          Panobinostat could be used synergistically with Daratumumab in a clinical setting to increase response rates and extend duration of responses

                          1 Reply Last reply
                          0
                          • B Offline
                            B Offline
                            bibob
                            wrote on sidst redigeret af
                            #871

                            Tak GB 😉

                            1 Reply Last reply
                            0
                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #872

                              Kan du vurdere, gentogen, om det er mere effektivt end ATRA til opregulering af CD38? Ved du om der er studier på vej dara+pano?

                              1 Reply Last reply
                              0
                              • S Offline
                                S Offline
                                Sun
                                wrote on sidst redigeret af
                                #873

                                Det er lige en kommentar til snakken igår omkring Darzalex og solide tumorer. @ Fantomas: Ang behandling af solide tumorer med antistoffer, så er dette allerede en succes ved brystkræft. Så det kan ikke passe at antistofferne ikke kan bruges til behandling af solide tumorer. Solide tumorer skal også have næring via blodet, og får cancercellerne ikke næring dør de. Så kommer der antistoffer i blodet, leveres de også til cancercellerne.

                                1 Reply Last reply
                                0
                                • G Offline
                                  G Offline
                                  gentogen
                                  wrote on sidst redigeret af
                                  #874

                                  Ved ikke mere Bulder, men "a large Phase III trial of panobinostat, a new type of myeloma drug called a HDAC inhibitor, were reported. Panobinostat is likely to be the next new agent to be approved by the FDA for relapsed/refractory multiple myeloma. This study evaluated panobinostat in combination with Velcade-dex and showed significantly improved outcomes as compared to Velcade-dex alone". http://multiplemyelomablog.com/2014/06/asco-news-panobinostat-sar650984-and-daratumumab.html

                                  1 Reply Last reply
                                  0
                                  • G Offline
                                    G Offline
                                    gentogen
                                    wrote on sidst redigeret af
                                    #875

                                    Altså en gammel nyhed fra ASCO 14

                                    1 Reply Last reply
                                    0
                                    • BulderB Offline
                                      BulderB Offline
                                      Bulder
                                      wrote on sidst redigeret af
                                      #876

                                      ja, i mellemtiden er pano blevet godkendt. Så nu har vi 3 stoffer der potentielt kan hjælpe mod dara-resistens: ATRA, Sepantronium bromide (YM155) og nu Panobonistat.

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                                      0
                                      • BulderB Offline
                                        BulderB Offline
                                        Bulder
                                        wrote on sidst redigeret af
                                        #877

                                        Panobino...

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                                        0
                                        • S Offline
                                          S Offline
                                          Sukkeralf
                                          wrote on sidst redigeret af
                                          #878

                                          Og da panobino stat tillige har andre virkningsmekanismer, så kunne det være sjovt at se den.

                                          1 Reply Last reply
                                          0

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